PMID: 9659816Jul 11, 1998Paper

HMGI family proteins: architectural transcription factors in mammalian development and cancer

The Keio Journal of Medicine
X Zhou, K Chada

Abstract

The HMGI proteins, a subfamily of the high mobility group (HMG) proteins, play an important role in the regulation of gene expression. They bind to AT-rich DNA sequences and alter DNA conformation to modulate the binding affinity of transcription factors to their cognate sites. They are expressed almost exclusively during embryogenesis and Hmgi-c null mice have the mouse pygmy phenotype. Studies have revealed the disruption of HMGI family genes in a variety of mesenchymal-derived benign tumors. Therefore, the HMGI genes function in the coordination of cell proliferation and differentiation during mammalian development.

Citations

Jan 1, 2001·Indian Journal of Clinical Biochemistry : IJCB·D Singh, M R Rajeswari
Feb 9, 2007·Journal of Cross-cultural Gerontology·Noriko Tsukada, Yasuhiko Saito
Jun 5, 2003·Cancer Genetics and Cytogenetics·Hena R AsharKiran Chada
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·J M AngelastroL A Greene
Mar 17, 2007·Acta Oto-laryngologica·Young Soo RhoHyung Sik Shin
Apr 7, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Jul 5, 2005·Pathology, Research and Practice·Katsuaki SatoShogo Katsuda
Jul 28, 2006·Molecular and Cellular Neurosciences·Hiroaki OkudaMasaya Tohyama
Jul 26, 2016·Frontiers in Cell and Developmental Biology·Sonia Alonso-MartinFrédéric Relaix
Mar 31, 2000·Nature Genetics·A Anand, K Chada
Oct 24, 2017·Asian-Australasian Journal of Animal Sciences·Jianping QuanJie Yang
Sep 25, 2018·The Journal of Clinical Endocrinology and Metabolism·Miao LiZi-Jiang Chen
May 6, 2020·International Journal of Molecular Sciences·Uchenna UnachukwuJeanine D'Armiento
Mar 3, 2007·Cancer Research·Jeanine D'ArmientoKiran Chada
Aug 4, 2006·Cancer Research·M Raza ZaidiKiran K Chada
Oct 23, 2004·Pathology, Research and Practice·Takuya AkaiKiran Chada

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