PMID: 9421825Jan 9, 1998Paper

HMPAO SPECT brain imaging in treatment-resistant depression

Progress in Neuro-psychopharmacology & Biological Psychiatry
M HornigJ D Amsterdam

Abstract

1. There is little published research on brain function in treatment-resistant depression (TRD). This study examined regional cerebral blood flow using 99mTechnetium-hexamethylpropanolamine oxime (HMPAO) single photon emission computed tomography in 8 patients with a history of TRD, 13 depressed patients without TRD (non-TRD) and 16 normal controls. 2. Relative HMPAO activity in selected brain regions revealed a significant increase in hippocampus-amygdala activity in TRD patients compared to non-TRD patients and healthy controls. The mean value of relative HMPAO activity did not differ in any other brain region, nor were there any differences in right-left symmetry among the subject groups. 3. The observation of increased hippocampus-amygdala HMPAO activity in TRD patients suggests that functional abnormalities in limbic circuitry may play a role in the pathophysiology of treatment-resistance.

References

Jan 1, 1979·Annual Review of Neuroscience·B S McEwenD W Pfaff
Jan 1, 1992·Journal of Affective Disorders·J D Amsterdam, P D Mozley
Apr 11, 1992·The American Journal of Psychiatry·J C WuW E Bunney
Jul 11, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H W Müller-GärtnerJ J Frost
May 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B E Murphy
Apr 1, 1991·Journal of Clinical Psychopharmacology·B E MurphyR Keller
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B E Murphy
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Duckrow
Jun 1, 1991·The American Journal of Psychiatry·R Guscott, P Grof
Jan 1, 1989·The Journal of Neuropsychiatry and Clinical Neurosciences·R A O'ConnellL N King
Mar 1, 1989·Archives of General Psychiatry·P Silfverskiöld, J Risberg
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Jan 1, 1985·International Journal of Nuclear Medicine and Biology·P SomR A Fawwaz
Dec 1, 1984·Archives of General Psychiatry·M S BuchsbaumJ Morihisa
Mar 1, 1995·Psychological Medicine·C J BenchR J Dolan
Sep 1, 1994·Archives of General Psychiatry·I M LesserM Wohl
Dec 1, 1993·Journal of Affective Disorders·P ThomasM Goudemand
Apr 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·P D MozleyJ D Amsterdam
Jun 1, 1996·The Psychiatric Clinics of North America·J D Amsterdam, M Hornig-Rohan
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Wayne C DrevetsMarcus E Raichle
Sep 5, 2001·Journal of Affective Disorders·E MervaalaJ Lehtonen
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego A Pizzagalli
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie-Laure Paillère MartinotEric Artiges
Feb 13, 2009·Journal of Affective Disorders·Ti-Jiang ZhangQi-Yong Gong
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wei-Jen YaoHong-Dun Lin
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Frank V SchramlBrian P Brown
Mar 17, 2007·The Psychiatric Clinics of North America·Darin D Dougherty, Scott L Rauch
Aug 8, 2013·Journal of Biochemical and Molecular Toxicology·Bingjin LiRanji Cui
Apr 28, 2004·NeuroImage·D A SeminowiczS Rafi-Tari
Jul 14, 2006·Psychiatry Research·Kazuhisa SegawaToshi A Furukawa
Mar 19, 2015·Frontiers in Psychiatry·Bart P de KwaastenietDamiaan Denys
Aug 10, 2017·Depression and Anxiety·Anca-Larisa SanduMarie-Laure Paillère Martinot
Jul 9, 2011·Issues in Mental Health Nursing·Cheryl Leslie van Daalen-Smith
May 2, 2003·Annals of the New York Academy of Sciences·Wayne C Drevets

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.