PMID: 8942985Nov 26, 1996Paper

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

Proceedings of the National Academy of Sciences of the United States of America
S AcharyaR Fishel

Abstract

The genetic and biochemical properties of three human MutS homologues, hMSH2, hMSH3, and hMSH6, have been examined. The full-length hMSH6 cDNA and genomic locus were isolated and characterized, and it was demonstrated that the hMSH6 gene consisted of 10 exons and mapped to chromosome 2p15-16. The hMSH3 cDNA was in some cases found to contain a 27-bp deletion resulting in a loss of nine amino acids, depending on the individual from which the cDNA was isolated. hMSH2, hMSH3, and hMSH6 all showed similar tissue-specific expression patterns. hMSH2 protein formed a complex with both hMSH3 and hMSH6 proteins, similar to protein complexes demonstrated by studies of the Saccharomyces cerevisiae MSH2, MSH3, and MSH6. hMSH2 was also found to form a homomultimer complex, but neither hMSH3 nor hMSH6 appear to interact with themselves or each other. Analysis of the mismatched nucleotide-binding specificity of the hMSH2-hMSH3 and hMSH2-hMSH6 protein complexes showed that they have overlapping but not identical binding specificity. These results help to explain the distribution of mutations in different mismatch-repair genes seen in hereditary nonpolyposis colon cancer.

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Citations

Feb 26, 1999·Environmental and Molecular Mutagenesis·Z YuB W Glickman
Apr 24, 2001·Environmental and Molecular Mutagenesis·A Ronen, B W Glickman
Dec 18, 2001·Genes, Chromosomes & Cancer·Marta Szadkowski, Josef Jiricny
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Feb 5, 1999·The Biochemical Journal·G Marra, P Schär

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