Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion.

Developmental Biology
Lely A QuinaEric E Turner

Abstract

Hmx1 is a variant homeodomain transcription factor expressed in the developing sensory nervous system, retina, and craniofacial mesenchyme. Recently, mutations at the Hmx1 locus have been linked to craniofacial defects in humans, rats, and mice, but its role in nervous system development is largely unknown. Here we show that Hmx1 is expressed in a subset of sensory neurons in the cranial and dorsal root ganglia which does not correspond to any specific sensory modality. Sensory neurons in the dorsal root and trigeminal ganglia of Hmx1dm/dm mouse embryos have no detectable Hmx1 protein, yet they undergo neurogenesis and express sensory subtype markers normally, demonstrating that Hmx1 is not globally required for the specification of sensory neurons from neural crest precursors. Loss of Hmx1 expression has no obvious effect on the early development of the trigeminal (V), superior (IX/X), or dorsal root ganglia neurons in which it is expressed, but results in marked defects in the geniculate (VII) ganglion. Hmx1dm/dm mouse embryos possess only a vestigial posterior auricular nerve, and general somatosensory neurons in the geniculate ganglion are greatly reduced by mid-gestation. Although Hmx1 is expressed in geniculate neurons pr...Continue Reading

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Citations

Jun 20, 2014·PloS One·Fabienne MarcelliDaniel F Schorderet
Sep 12, 2015·The Journal of Comparative Neurology·Szilard SajgoTudor Constantin Badea
Oct 17, 2012·Experimental Eye Research·Gaëlle Boisset, Daniel F Schorderet
Feb 6, 2014·Developmental Biology·Cedric PattheySebastian M Shimeld
Feb 12, 2014·Developmental Biology·Melinda S ModrellClare V H Baker
Sep 1, 2017·The Journal of Comparative Neurology·Lisa Ohman-GaultRobin Krimm
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Simon VermeirenSimon Desiderio
Jan 20, 2021·PloS One·Younes El FersiouiDaniel F Schorderet

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