HNF1β and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies

Cancer Cytopathology
James R ConnerVickie Y Jo

Abstract

Morphologic overlap between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC) can pose diagnostic challenges, especially in biopsy samples in which tumor quantity may be limited, architectural features are not well represented, and gross examination is not possible. It has been demonstrated that immunohistochemistry (IHC) for HNF1α, HNF1β, and S100A1 are differentially expressed in RO and ChRCC in resection specimens. We evaluated the utility of these markers in FNA and core biopsies of RO and ChRCC. IHC for HNF1α, HNF1β, and S100A1 were performed on 61 RO specimens (36 FNA biopsies and 25 core biopsies) and on 14 ChRCC specimens (10 FNA biopsies and 4 core biopsies), and results were scored semiquantitatively for staining intensity (0-3: negative, weak, moderate, strong) and staining extent (0-4: 0%, 1-25%, 26-50%, 51-75%, 76-100%). Forty-four (44) of 60 (73%) RO displayed moderate-to-strong nuclear reactivity for HNF1β compared to 3 of 14 (21%) ChRCC (P < .001). Staining was present in >50% of tumor cells in 34 of 60 (57%) RO and in 2 of 14 (14%) ChRCC (P = .004). S100A1 was moderately-to-strongly positive in 45 of 56 (80%) RO and in 1 of 13 (8%) ChRCC (P < .001), with 39 of 56 (70%) and 2 of 13 (15%) cases, ...Continue Reading

References

Apr 1, 1992·Genes, Chromosomes & Cancer·A Kovacs, G Kovacs
Sep 1, 1995·The Journal of Urology·T B CrottyM M Lieber
Oct 15, 1996·Cancer·A A RenshawD S Weinberg
Jan 1, 1997·The American Journal of Surgical Pathology·M B AminG M Farrow
Jul 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sang Ling WuJohn H Connelly
Oct 9, 2002·Acta Cytologica·Wendy S MorelandKim R Geisinger
Feb 8, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steven S ShenLuan D Truong
May 8, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paolo Cossu RoccaGuido Martignoni
Jan 31, 2013·Development·Filippo MassaEvelyne Fischer

❮ Previous
Next ❯

Citations

Nov 29, 2015·The Urologic Clinics of North America·Li Yan Khor, Puay Hoon Tan
Aug 10, 2020·Indian Journal of Pathology & Microbiology·Nehal S AbouhashemMohamed El-Shazly
May 13, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jay AminEric C Kauffman
Oct 15, 2020·Scientific Reports·Michaela BártůPavel Dundr
Feb 20, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Zeliha B SariErtuğrul Çolak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.