HNH family subclassification leads to identification of commonality in the His-Me endonuclease superfamily

Protein Science : a Publication of the Protein Society
Preeti MehtaSankaran Krishnaswamy

Abstract

The HNHc (SMART ID: SM00507) domain (SCOP nomenclature: HNH family) can be subclassified into at least eight subsets by iterative refinement of HMM profiles. An initial clustering of 323 proteins containing the HNHc domain helped identify the subsets. The subsets could be differentiated on the basis of the pattern of occurrence of seven defining features. Domain association is also different between the subsets. The subsets show organism as well as domain-based clustering, suggestive of propagation by both duplication and horizontal transfer events. Structure-based sequence analysis of the subsets led to the identification of common structural and sequence motifs in the HNH family with the other three families under the His-Me endonuclease superfamily.

References

Oct 25, 1990·Nucleic Acids Research·T D Schneider, R M Stephens
Jul 1, 1994·Protein Science : a Publication of the Protein Society·A E Gorbalenya
Mar 13, 1999·Nature Structural Biology·C KleanthousA M Hemmings
May 18, 1999·Journal of Molecular Biology·M D MillerK L Krause
Feb 27, 2001·Nucleic Acids Research·S Zimmerly Wu Xc
Apr 9, 2001·Nucleic Acids Research·N V Grishin

❮ Previous
Next ❯

Citations

Oct 28, 2008·Nature Structural & Molecular Biology·Wei Yang
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Timur Yusufzai, James T Kadonaga
Jan 5, 2011·The Journal of Biological Chemistry·Marielle C GruenigMichael M Cox
Sep 6, 2011·Nucleic Acids Research·Gregory K TaylorBarry L Stoddard
Jun 10, 2008·Applied and Environmental Microbiology·Evelyn DurmazTodd R Klaenhammer
Oct 9, 2012·Applied and Environmental Microbiology·Mariángeles Briggiler MarcóSylvain Moineau
Sep 11, 2007·BMC Evolutionary Biology·Peik HaugenKathleen M Pryer
Nov 30, 2007·BMC Genomics·Chia-Ni LeeShu-Fen Weng
Jun 24, 2014·Journal of Computer-aided Molecular Design·Eszter NémethChris Oostenbrink
Aug 27, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Eszter NémethBéla Gyurcsik
Nov 17, 2009·Cellular and Molecular Life Sciences : CMLS·Maria J MarcaidaGuillermo Montoya
Jan 22, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anikó CzeneBéla Gyurcsik
Apr 9, 2013·Protein Expression and Purification·Béla GyurcsikZoltán Kele
Mar 22, 2012·Protein Science : a Publication of the Protein Society·Serisha MoodleyVoula Kanelis
Jun 5, 2014·Protein Science : a Publication of the Protein Society·Eszter NémethBéla Gyurcsik
Aug 18, 2004·Journal of Molecular Biology·Betty W ShenBarry L Stoddard
Jul 19, 2005·Biochimica Et Biophysica Acta·Edita KriukieneArvydas Lubys
Oct 26, 2016·Protein Science : a Publication of the Protein Society·Eszter NémethBéla Gyurcsik
Oct 19, 2017·Nucleic Acids Research·Jagoda JablonskaKrzysztof Ginalski
Feb 22, 2012·Chembiochem : a European Journal of Chemical Biology·Marika MidonAlfred Pingoud
Jun 18, 2017·Nature Communications·Marek SebestaDragana Ahel
Jan 16, 2021·Nucleic Acids Research·Michal PastorMatthias Bochtler
Jul 22, 2021·Applied and Environmental Microbiology·Piyush Behari LalPatricia J Kiley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.