HNP-1 and HBD-1 as Biomarkers for the Immune Systems of Elite Basketball Athletes

Antibiotics
Raffaela PeroOlga Scudiero

Abstract

Acute or strenuous exercise is sometimes related to upper respiratory tract infections in athletes. Practicing intense and regular exercise can lead to incorrect activation of the immune system, causing athletes to be excluded from training programs and competitions. Defensins are small antimicrobial peptides that are part of the innate immune system and dynamically involved in several biological activities. In this study, we highlight the role of human defensins in competitive basketball athletes. In particular, we consider the behavior of alpha- and beta-defensins together with white blood cells in a cohort of players. Moreover, we focus our attention on cortisol, a physiological indicator of stress, and testosterone, both of which are human hormones involved in muscle metabolism. The free-testosterone/cortisol ratio is considered to be an indicator of overtraining among athletes. This paper provides an up-to-date information of the role of human defensins as self-defense molecules during a continuous stressor such as long-term exercise, and it recognizes them as potential markers of infection.

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Citations

Jan 27, 2021·International Journal of Environmental Research and Public Health·Olga ScudieroGiulia Frisso
Feb 11, 2021·International Journal of Environmental Research and Public Health·Mariarita BrancaccioOlga Scudiero
Dec 20, 2020·International Journal of Environmental Research and Public Health·Mariarita BrancaccioOlga Scudiero
Jul 3, 2021·Microorganisms·Sonia LaneriRaffaela Pero

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BETA
ELISA

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GraphPad
GraphPad Prism

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