hnRNP-R regulates the PMA-induced c-fos expression in retinal cells

Cellular & Molecular Biology Letters
Jia HuangPing Xu

Abstract

This study focused on the function of hnRNP-R in the regulation of c-fos expression. We demonstrated that hnRNP-R accelerated the rise and decline phases of c-fos mRNAs and Fos proteins, allowing PMA to induce an augmented pulse response of c-fos expression. Then, we examined the role of the c-fos-derived AU-rich element (ARE) in hnRNP-R-regulated mRNA degradation. Studies with the ARE-GFP reporter gene showed that hnRNP-R significantly reduced the expression of GFP with an inserted ARE. Moreover, immunoprecipitation-RT-PCR analysis demonstrated that in R28 cells and rat retinal tissues, the c-fos mRNA was co-immunoprecipitated with hnRNP-R. These findings indicate that hnRNP-R regulates the c-fos expression in retinal cells, and that the ARE of c-fos mRNAs contributes to this regulation.

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Citations

Dec 24, 2010·Journal of Gastroenterology and Hepatology·Guang-Jun JingHai-Yan Kong
Nov 19, 2008·Neurochemical Research·Zheng-Yu PengPing Xu
Mar 23, 2011·Neurochemical Research·Zhong-Hui WangXian-Hua Chen
Aug 16, 2014·The Journal of Biological Chemistry·Mumtaz KasimMichael Fähling
Feb 14, 2019·Acta Neuropathologica Communications·Lauren M GittingsTammaryn Lashley

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