hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers

Molecular Oncology
Yang XuanWuguo Deng

Abstract

Cyclooxygenase-2 (COX-2) is highly expressed in tumor cells and has been regarded as a hallmarker for cancers, but the excise regulatory mechanism of COX-2 in tumorigenesis remains largely unknown. Here, we pulled down and identified a novel COX-2 regulator, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1), which could specifically bind to COX-2 core promoter and regulate tumor growth in non-small-cell lung cancers (NSCLCs). Knockdown of hnRNPA2/B1 by shRNA or siRNA downregulated COX-2 expression and prostaglandin E2 (PGE2) production, and suppressed tumor cell growth in NSCLC cells in vitro and in vivo. Conversely, overexpression of hnRNPA2/B1 up-regulated the levels of COX-2 and PGE2 and promoted tumor cell growth. We also showed that hnRNPA2/B1 expression was positively correlated with COX-2 expression in NSCLC cell lines and tumor tissues, and the up-regulated expression of hnRNPA2/B1 and COX-2 predicted worse prognosis in NSCLC patients. Furthermore, we demonstrated that the activation of COX-2 expression by hnRNPA2/B1 was mediated through the cooperation with p300, a transcriptional co-activator, in NSCLC cells. The hnRNPA2/B1 could interact with p300 directly and be acetylated by p300. Exogenous overexpression ...Continue Reading

References

Apr 15, 2003·The Journal of Pathology·D R J SneadH Kamma
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Irene PinoLuis M Montuenga
Feb 17, 2005·The New England Journal of Medicine·Scott D SolomonUNKNOWN Adenoma Prevention with Celecoxib (APC) Study Investigators
Jul 15, 2005·Journal of Cell Science·Yaowu HeRoss Smith
Nov 19, 2005·Science·Maria Domenica CastelloneJ Silvio Gutkind
Jun 9, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Wu-Guo DengKenneth K Wu
Jul 3, 2009·Current Opinion in Pharmacology·Jordi Tauler, James L Mulshine
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia V ClowerAdrian R Krainer
Aug 28, 2010·The Biochemical Journal·Siew Ping HanRoss Smith
Sep 3, 2010·Cancer Research·Jordi TaulerJames L Mulshine
Dec 29, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria Teresa Rizzo
Mar 1, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Hideki MizunoShuichi Kaneko
Mar 1, 2014·Journal of Clinical Medicine Research·Fahad Aziz
Mar 7, 2014·International Journal of Cancer. Journal International Du Cancer·Andrea MarkkulaHelena Jernström
Jun 28, 2014·Endocrine-related Cancer·Xin QiuPeter C K Leung
Jul 21, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Qingli LiZongbing You
Aug 22, 2014·Journal of Cellular Biochemistry·Mahnaz NorouziMona Salimi
Sep 4, 2014·Respiratory Care·Angeliki N FlorouKonstantinos N Syrigos
Oct 11, 2014·World Journal of Clinical Oncology·Yuichi TakiguchiKoichiro Tatsumi
Dec 17, 2014·Annals of Global Health·Yuan-Chin Amy Lee, Mia Hashibe
Dec 17, 2014·Annals of Global Health·Dana Hashim, Paolo Boffetta
Jul 8, 2015·The Lancet Oncology·Baoqing ChenJianxin Xue

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Citations

Dec 29, 2017·International Journal of Molecular Sciences·Jung-Chun Lin
Oct 21, 2018·Journal of Cellular Physiology·Nasser Hashemi GoradelKeywan Mortezaee
Jun 27, 2020·Wiley Interdisciplinary Reviews. RNA·Yu Liu, Song-Lin Shi
Jan 1, 2020·Clinical Proteomics·Ulana KotowskiGoran Mitulović
Apr 19, 2019·Antioxidants·Meenakshi SudhakaranAndrea I Doseff

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