Abstract
Although Hodgkin lymphoma-like posttransplantation lymphoproliferative disorder (HL-like PTLD) has been grouped with classic Hodgkin lymphoma type PTLD (HL-PTLD), controversy remains as to whether it is truly a form of HL or whether it should be more appropriately classified as a form of B-cell PTLD. Because only few cases of HL-like PTLD have been reported, their pathologic nature and clinical behavior have not been well defined. This report characterized 5 cases of HL-like PTLD with respect to their immunophenotype, EBV status, clonality, and clinical outcome. All of the patients were male, with ages ranging from 1.5 to 55 years at diagnosis. PTLD developed from 4 months to 6 years following solid organ transplantation (3 hearts, 1 kidney, 1 liver), and involved both nodal and extranodal sites. All were EBV-related (EBER+) with the large neoplastic cells CD20/CD79a positive but CD15 negative. Immunoglobulin gene rearrangements were detected in 3 of 5 tested. All patients were managed by initial reduction/withdrawal of immunosuppression, with 2 also receiving chemotherapy for non-HL. Three patients died of progressive disease within 2 to 3 months after diagnosis, 1 is alive and well 2 years later, and the fifth was disease fre...Continue Reading
References
Feb 1, 1977·American Journal of Surgery·J CerilliW S Rothermel
Aug 1, 1989·The American Journal of Medicine·K J OldhaferR Pichlmayr
Mar 1, 1974·Transplantation·W A SterlingA G Diethelm
Jan 15, 1983·Cancer·T J DoyleE J Tilchen
Dec 1, 1994·Human Pathology·G H SegalR C Braylan
Dec 1, 1994·Human Pathology·G H SegalR C Braylan
Nov 1, 1993·Cancer·M A NalesnikJ Locker
Jan 15, 1996·Transplantation·J L GarnierJ L Touraine
Mar 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P J BiermanT C Greiner
Oct 1, 1996·The Journal of Experimental Medicine·H KanzlerK Rajewsky
Nov 1, 1996·Journal of Pediatric Hematology/oncology·R K GoyalD B Wilson
Feb 1, 1997·Mayo Clinic Proceedings·D E MidthunJ P Scott
Apr 1, 1997·Human Pathology·R ChettyK Gatter
Apr 22, 1999·The New England Journal of Medicine·A BräuningerR Küppers
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A RowlingsM M Horowitz
Feb 7, 2001·Transplantation·P SchneiterL Tappy
Feb 7, 2001·Transplantation·F SmetsE Sokal
Feb 24, 2001·Journal of Pediatric Hematology/oncology·R J HayashiM R DeBaun
Jan 17, 2002·Transplantation·Erik A M VerschuurenWim van Der Bij
Feb 28, 2002·American Journal of Clinical Pathology·Margaret L GulleyRichard F Ambinder
Jun 20, 2002·Transplantation Proceedings·P-T T PhamG M Danovitch
Jan 28, 2003·Lancet·Judith M TimmsHenri-Jacques Delecluse
Mar 11, 2004·Pediatric Transplantation·Vikas R DharnidharkaRobert S Fennell
Apr 24, 2004·The American Journal of Surgical Pathology·Qin HuangLawrence M Weiss
Citations
Apr 13, 2011·Hepatology International·Morteza IzadiSaeed Taheri
Jun 26, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Krzysztof MuchaLeszek Paczek
Apr 9, 2010·Clinical Microbiology Reviews·Margaret L Gulley, Weihua Tang
May 29, 2009·Journal of Clinical and Experimental Hematopathology : JCEH·Keisuke OkunoKazuhiko Hayashi
Jun 6, 2013·Case Reports in Hematology·Kristin La FortuneErik A Ranheim
Dec 1, 2013·Surgical Pathology Clinics·Lawrence M Weiss
May 11, 2012·Pathology, Research and Practice·Endi WangSiby Sebastian
Apr 8, 2010·Pediatric Clinics of North America·Thomas G GrossAngela Punnett
Sep 3, 2013·Pediatric Transplantation·Sabrina BassoPatrizia Comoli
Jan 26, 2011·Journal of Cutaneous Pathology·Begoña VieitesFrancisco Carvajo
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A VaglioU Maggiore
Apr 18, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ekkehard HewerAnja M Schmitt
Sep 19, 2015·Blood·Daan DierickxOlivier Gheysens
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Aghil Gholipour-ShoiiliSaeed Taheri
Sep 25, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Thomas LoweGeorge Somlo
Mar 2, 2016·American Journal of Hematology·Aaron S RosenbergAndrew M Evens
Nov 30, 2016·Journal of Clinical Pathology·Chee Leong Cheng, Simon O'Connor
Jul 7, 2009·International Journal of Surgical Pathology·Smita KrishnamurthyFriederike H Kreisel
Jan 31, 2018·International Journal of Hematology·Taro MohriYasuhiro Iwai
Dec 1, 2007·Advances in Anatomic Pathology·Colan Ho-YenSebastian Lucas
Apr 25, 2007·Advances in Anatomic Pathology·Jonathan W Said
May 8, 2019·Pediatric Blood & Cancer·Clare J TwistSarah S Donaldson
Jan 26, 2011·American Journal of Hematology·Antonino CarboneUmberto Tirelli
May 23, 2019·The American Journal of Surgical Pathology·Daisuke KuritaKoichi Ohshima
Aug 27, 2009·Expert Opinion on Therapeutic Targets·Heiner AdamsAlexandar Tzankov
Sep 4, 2020·Leukemia & Lymphoma·Ryan J StubbinsAnthea C Peters
Mar 7, 2021·Cancers·Eric LauHuynh Cao
May 29, 2021·Expert Review of Hematology·Antonino CarboneEmanuela Vaccher