Hodgkin's disease and human immunodeficiency virus infection: clinicopathologic and virologic features of 114 patients from the Italian Cooperative Group on AIDS and Tumors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
U TirelliA Carbone

Abstract

To describe virologic, clinicopathologic, and therapeutic features of a large series of Italian patients with Hodgkin's disease (HD) and human immunodeficiency virus (HIV) infection. From November 1986 to March 1994, 114 cases were observed. The relationship between Epstein-Barr virus (EBV) and HD was determined by an in situ hybridization technique, immunostaining for EBV-encoded latent membrane protein-1 (LMP-1) expression, and Southern blotting. Twenty-six patients were included in a prospective study evaluating the combination of chemotherapy (CT) with zidovudine. Combined approach on EBV study revealed that 14 (78%) of 18 patients were EBV-associated. An almost equivalent distribution of EBV subtypes was observed in EBV-carrying cases, indicating that in the HIV setting, type 2 EBV also may be pathogenetically involved in HD development. In comparing these 114 patients with our single-institutional series of 104 HIV-negative patients with HD, we observed at presentation a younger median age (29 v 38 years); a prevalence of males (90% v 56%); and a higher percentage of stage IV disease (52% v 15%), presence of B symptoms (77% v 35%), and extranodal disease (63% v 29%). The complete remission (CR) rate (58%) and median survi...Continue Reading

Citations

Feb 7, 1997·International Journal of Cancer. Journal International Du Cancer·S L GlaserA Claviez
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A RowlingsM M Horowitz
Apr 7, 2000·Leukemia & Lymphoma·T PerinA Carbone
May 17, 2000·AIDS Patient Care and STDs·B U Mueller
May 22, 2001·AIDS Patient Care and STDs·G J Roboz, J H Godwin
Jun 28, 2001·American Journal of Hematology·M SappM S Lim
Sep 14, 2001·Current Opinion in Oncology·C A Clarke, S L Glaser
Aug 21, 2001·Drugs·M J Kersten, R H Van Oers
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro ReMaurizio Mazzuccato
Sep 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph M Connors
Apr 3, 2009·Current Opinion in HIV and AIDS·Liron Pantanowitz, Bruce J Dezube
Apr 3, 2009·Current Opinion in HIV and AIDS·Amrita Krishnan
Jan 25, 2012·Advances in Hematology·Caron A Jacobson, Jeremy S Abramson
Jun 28, 2014·The Oncologist·Emanuela VaccherPaolo De Paoli
Mar 13, 2014·Nature Reviews. Clinical Oncology·Antonino CarboneSilvia Franceschi
Jun 24, 2014·American Journal of Hematology·Stephen M Ansell
Jul 1, 1996·Leukemia & Lymphoma·U TirelliE Vaccher
Apr 11, 2001·Current Oncology Reports·D J Straus
Oct 2, 2003·Bone Marrow Transplantation·A KrishnanS J Forman
Oct 7, 2003·Oncogene·Massimiliano BerrettaUmberto Tirelli
Nov 2, 2004·Nature Reviews. Cancer·Paolo MoniniBarbara Ensoli
Oct 29, 2008·Blood·Antonino CarboneThomas F Schulz
Apr 20, 2007·The Cochrane Database of Systematic Reviews·A J Martí-CarvajalM L Rodríguez
Jun 21, 2011·Advances in Hematology·Bhanu Vakkalanka, Brian K Link
Oct 10, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lawrence D Kaplan
May 2, 2012·Current Hematologic Malignancy Reports·Nihal Martis, Nicolas Mounier
Aug 30, 2014·American Journal of Epidemiology·Anna E Coghill, Allan Hildesheim
Dec 15, 2015·Expert Review of Hematology·Chia-Ching J Wang, Lawrence D Kaplan
Mar 24, 2016·American Journal of Hematology·Stephen M Ansell
Apr 11, 2018·American Journal of Hematology·Stephen M Ansell
Jun 20, 2018·Cancers·Nicholas MetiNathalie A Johnson
Apr 9, 1999·Sexually Transmitted Infections·A J WinterK W Radcliffe

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Gregory K RobbinsKenneth A Freedberg
The Journal of Infectious Diseases
William A BlattnerMichael Greenberg
World Journal of Gastroenterology : WJG
Golnaz BahramaliFereidoun Mahboudi
© 2021 Meta ULC. All rights reserved