PMID: 9162510Jan 1, 1997Paper

Hodgkin's disease trials conducted by the European Organization of Research and Treatment of Cancer (EORTC): their impact on the progress of cancerology

Bulletin de l'Académie nationale de médecine
P Carde

Abstract

Hodgkin's disease is a rare event that allowed key progress in the field of Oncology. Starting 1964 the EORTC has conducted a series of comprehensive controlled trials of outmost importance from the time of the first cures achieved with extended field radiotherapy until the observation that dose-response relationships could occur both for tumor control and for the incidence of second leukemia, cardiac, and pulmonary toxicities. Each of these steps is depicted in some detail. The contributions of the EORTC include in particular the first demonstration ever of the positive impact of an adjuvant chemotherapy on the freedom from progression and overall survival of a cancer (1964-1972), the identification of prognostic factors usable to adapt the aggressivity of treatment to patient's risks and the role of excess mortality from iatrogenic origin. Directions are indicated to insure a continuous progress to the Oncology field through additional Hodgkin's disease studies.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.