Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells

The New England Journal of Medicine
M HummelHarald Stein

Abstract

There is strong evidence that Reed-Sternberg cells have a lymphoid phenotype, but clonally rearranged genes for B-cell and T-cell antigen receptors have not been demonstrable in tumor tissue from most patients with Hodgkin's disease. To elucidate this issue, we assayed single Reed-Sternberg cells from 12 patients with classic Hodgkin's disease of a B-cell immunophenotype to detect rearranged immunoglobulin variable-region heavy-chain (VH) genes. We isolated single Reed-Sternberg cells from frozen sections that had been immunostained for CD30. The rearranged VH genes of these cells were amplified by the polymerase chain reaction and analyzed by gel electrophoresis and nucleotide sequencing. In all 12 patients, the Reed-Sternberg cells studied contained rearranged VH genes. Three patterns were observed: in three patients the rearrangements in each patient were identical, in six patients all the rearrangements were unrelated and unique, and in three patients both identical and unrelated rearrangements were detected. Apparently somatic mutations of VH genes were present in some Reed-Sternberg cells but absent in others. Reed-Sternberg cells with B-cell phenotypes have rearranged VH genes; therefore, these cells arise from B cells. ...Continue Reading

References

Jan 1, 1992·International Reviews of Immunology·J M Teale, C A Medina
Aug 15, 1992·Annals of Internal Medicine·N A HessolS D Holmberg
Oct 7, 1989·Lancet·F E Dallenbach, H Stein
Dec 1, 1989·Histopathology·M L CibullD Y Mason
Nov 1, 1989·Cancer Genetics and Cytogenetics·P R KoduruS C Jhanwar
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·M H FalkG W Bornkamm
Sep 1, 1988·Cancer Genetics and Cytogenetics·L TeerenhoviS Knuutila
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D M KnowlesR Dalla-Favera
Oct 1, 1986·Human Pathology·L M WeissJ Sklar
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·H SteinV Diehl
May 1, 1995·Immunology Today·G P Cook, I M Tomlinson
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·G InghiramiD M Knowles
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Wolf, V Diehl
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P C PasmanH C Schouten
Aug 1, 1993·Immunology Today·C Berek, M Ziegner
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R K GuptaJ G Bodmer

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Citations

Apr 1, 1997·The Journal of Pathology·J J OudejansC J Meijer
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·K OhshimaM Kikuchi
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·A Van den BergS Poppema
Mar 29, 2001·Hematological Oncology·W C Chan
May 25, 2001·International Journal of Hematology·K UehiraS Fukuhara
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A EngertV Diehl
Jun 4, 1999·Pathology International·I SakumaT Akagi
Oct 5, 1995·The New England Journal of Medicine·F K Stevenson
Aug 14, 1997·The New England Journal of Medicine·R S Schwartz
Feb 13, 1999·The New England Journal of Medicine·M HummelH Stein
Sep 24, 1999·Journal of the National Cancer Institute·U HasseM F Fey
Dec 6, 2003·The American Journal of Surgical Pathology·Todd S BarryStefania Pittaluga
Nov 5, 1999·Current Opinion in Oncology·M SpinaU Tirelli
Oct 15, 2005·The American Journal of Surgical Pathology·Alexandra Traverse-GlehenElaine S Jaffe
Apr 15, 2011·The American Journal of Surgical Pathology·Joo Y SongElaine S Jaffe
May 1, 1997·The British Journal of Dermatology·L CerroniH Kerl
May 29, 1998·Immunological Reviews·U KleinR Küppers
Feb 17, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C SambadeC Sundström
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A F LauritzenE Ralfkiaer
Sep 3, 2008·Veterinary Clinical Pathology·Jennifer D Steinberg, John H Keating
Nov 25, 2000·Molecular Pathology : MP·K J Flavell, P G Murray
May 23, 1998·Annual Review of Immunology·R Küppers, K Rajewsky
Aug 25, 2004·American Journal of Clinical Pathology·Adam Goldfarb
Jun 15, 2007·International Journal of Hematology·Makoto SaitoMasanobu Morioka
May 19, 2007·Journal of Clinical and Experimental Hematopathology : JCEH·Naoya NakamuraYoshiyuki Osamura
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J IrschA Radbruch
Jun 28, 2001·Journal of Cutaneous Pathology·M NihalG S Wood
Feb 8, 1996·The New England Journal of Medicine·R KüppersK Rajewsky
Dec 24, 1997·Leukemia & Lymphoma·K Clodi, A Younes

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