Hodotopy, neuroplasticity and diffuse gliomas

Neuro-Chirurgie
Hugues Duffau

Abstract

The historical approach in neurooncology is used to mainly investigate the tumor, with very few considerations regarding the brain itself. Nonetheless, to select the best personalized therapeutic management for each patient with a diffuse glioma, i.e. to optimize the "onco-functional balance", the brain reaction induced by glioma growth and migration should be studied. Indeed, due to strong interactions between the glioma and the brain, cerebral adaptive phenomena often occur in order to maintain neurological and cognitive functions, as well as to compensate glioma spreading. Here, the goal is to detail mechanisms underlying neuroplasticity and its implications for surgical neurooncology. Data issues from cerebral mapping and functional outcomes in patients who underwent awake surgery for gliomas were discussed. Massive resections of the brain, including so-called "eloquent areas", are possible without generating permanent neurological deficits in adult patients harbouring a diffuse glioma. From a fundamental point of view, these findings open the door to a hodotopical anatomo-functional organization of the brain, i.e. organized in dynamic and interactive parallel large-scale distributed networks, able to compensate for each ot...Continue Reading

Citations

Mar 10, 2018·Expert Review of Neurotherapeutics·François-Xavier Ferracci, Hugues Duffau
Jul 20, 2018·Brain Structure & Function·Thomas DecramerTom Theys
Jan 5, 2019·Brain Structure & Function·Christos KoutsarnakisGeorge Stranjalis
Jun 12, 2019·Scientific Reports·Stefanie BetteJens Gempt
Dec 9, 2020·Neurosurgery·Ramin A MorshedShawn L Hervey-Jumper
Apr 4, 2021·Journal of Clinical Medicine·Francesco LatiniMats Ryttlefors

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.