Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy

Biomaterials
Junjie LiuKaiyong Cai

Abstract

To efficiently deliver anti-cancer drug to tumor site and reduce its toxic side effects on normal tissues, a polyethylene glycol (PEG) shielding and tumor microenvironment triggering cascade pH-responsive hollow mesoporous silica nanoparticles (HMSNs) drug delivery system was fabricated. 3-(3, 4-dihydroxyphenyl) propionic acid (DHPA) functionalized beta-cyclodextrin (β-CD) was grafted onto the surfaces of HMSNs via boronic acid-catechol ester bonds. Then, PEG conjugated adamantane (Ada) was anchored on HMSNs-β-CD nanocarrier via host-gust interaction. Various techniques proved the successful fabrication of the system. The in vitro tests confirmed that the system was biocompatible. After the system permeating into tumor via enhanced permeability and retention (EPR) effect, the benzoic-imine bonds between the PEG and Ada were cleaved under weak acid condition in tumor microenvironment (pH 6.8), while the dissociated PEG protective layer facilitating cellular uptake of HMSNs system. Subsequently, the boronic acid-catechol ester bonds linkers further hydrolyzed under even low endosomal pH (4.5-6.5) condition for intracellular drug delivery, leading to efficient cell apoptosis. The in vivo results demonstrated that drug loaded HMSNs...Continue Reading

References

Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
May 1, 2009·Journal of the American Chemical Society·Elena AznarCarmen Guillem
Oct 6, 2009·Journal of the American Chemical Society·Li DuJeffrey I Zink
Dec 10, 2009·Nature Reviews. Molecular Cell Biology·Joseph R CaseyJohn Orlowski
Jun 18, 2010·ACS Nano·Eudald CasalsVictor Puntes
Jan 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shanta DharOmid C Farokhzad
Jun 17, 2011·Accounts of Chemical Research·Michael W AmbrogioJ Fraser Stoddart
Dec 24, 2011·Journal of the American Chemical Society·Carl D WalkeyWarren C W Chan
Jul 4, 2012·International Journal of Cancer. Journal International Du Cancer·Freddie BrayJacques Ferlay
Feb 8, 2013·Accounts of Chemical Research·Derrick TarnC Jeffrey Brinker
May 7, 2013·Colloids and Surfaces. B, Biointerfaces·Ping LuoShiyuan Liu
Oct 10, 2013·Chemistry : a European Journal·Yunfeng JiaoWuli Yang
Nov 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuichi KoyamatsuMizuo Maeda
May 21, 2014·Journal of the American Chemical Society·Xiaochen A WuChad A Mirkin
Nov 20, 2014·Chemical Society Reviews·Claudia CaltagironeRiccardo Montis
Feb 24, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ying WangSiling Wang
Mar 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Susumu HamaKentaro Kogure

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Citations

Jul 25, 2017·Nanomaterials·Anna Watermann, Juergen Brieger
Jan 10, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·E CarazoC Viseras
Mar 7, 2019·Advanced Healthcare Materials·Haiwei WuXuejian Liu
Apr 25, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Menghuan LiKaiyong Cai
Aug 15, 2019·Nanomedicine·Francisco ArriagadaJavier Morales
Dec 6, 2019·International Journal of Molecular Sciences·Jacob W ShrefflerAmanda E Brooks
May 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhonglong LiuYue He
Jun 8, 2017·Journal of Materials Science. Materials in Medicine·Tao YangLei Sui
Sep 28, 2017·Bioengineering·Miguel Gisbert-GarzaránMaría Vallet-Regí
Oct 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xi WenYa-Ping Guo
Nov 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Junjie LiuKaiyong Cai
Jun 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K TamarovV-P Lehto
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Apr 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·A BaezaM Vallet-Regí
Aug 8, 2020·Frontiers in Chemistry·Vanitha SelvarajanPui Lai Rachel Ee
Oct 27, 2017·Pharmaceutical Development and Technology·Dinghu ZhangQin Liu
Oct 24, 2017·Chemical Communications : Chem Comm·Yuanyuan ZhangYanli Zhao

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