Holographic optogenetic stimulation of patterned neuronal activity for vision restoration

Nature Communications
Inna Reutsky-GefenS Shoham


When natural photoreception is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits. Recently, light-sensitive proteins that photosensitize quiescent neurons have generated unprecedented opportunities for optogenetic neuronal control, inspiring early development of optical retinal prostheses. Selectively exciting large neural populations are essential for eliciting meaningful perceptions in the brain. Here we provide the first demonstration of holographic photo-stimulation strategies for bionic vision restoration. In blind retinas, we demonstrate reliable holographically patterned optogenetic stimulation of retinal ganglion cells with millisecond temporal precision and cellular resolution. Holographic excitation strategies could enable flexible control over distributed neuronal circuits, potentially paving the way towards high-acuity vision restoration devices and additional medical and scientific neuro-photonics applications.


Apr 1, 1997·Archives of Ophthalmology·A SantosA H Milam
Jan 1, 1997·Spatial Vision·D H Brainard
Jun 25, 1999·The British Journal of Ophthalmology·S BeattyI J Murray
Jul 2, 2004·Neural Computation·R Quian QuirogaY Ben-Shaul
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Nov 10, 2005·Nature Methods·Shy ShohamSamuel S-H Wang
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·H WangG J Augustine
May 25, 2007·Neuron·Stephanie SzobotaEhud Y Isacoff
May 26, 2007·Investigative Ophthalmology & Visual Science·Michel PaquesJosé-Alain Sahel
Jun 8, 2007·IEEE Transactions on Bio-medical Engineering·Alon AsherDaniel V Palanker
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Hiroshi TomitaMakoto Tamai
Jan 12, 2008·Journal of Neuroscience Methods·Luke CampagnolaMark J Zylka
Dec 24, 2008·Optics Express·Eirini PapagiakoumouValentina Emiliani
Jan 9, 2009·Frontiers in Neural Circuits·Volodymyr NikolenkoRafael Yuste
Jan 23, 2009·Nature Methods·Christoph LutzValentina Emiliani
Feb 19, 2007·Optics Express·Roberto Di LeonardoGiancarlo Ruocco
Oct 20, 2009·Journal of Neural Engineering·L GolanS Shoham
Nov 10, 2009·Nature Methods·Zengcai V GuoSharad Ramanathan
Jan 16, 2010·Journal of Neural Engineering·Nir GrossmanPatrick Degenaar
Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Senthil ThyagarajanHeinz Wässle
Sep 21, 2010·Nature Methods·Eirini PapagiakoumouValentina Emiliani
Oct 5, 2010·Nature Methods·Shy Shoham
Jan 18, 2011·Nature Methods·Andrew M LeiferAravinthan D T Samuel
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·M Mehdi DoroudchiAlan Horsager
May 31, 2011·Journal of Neural Engineering·Sunggu YangValentina Emiliani
Jan 3, 2012·Current Opinion in Neurobiology·Alipasha Vaziri, Valentina Emiliani
Jan 26, 2012·Optics Express·Suhail MatarShy Shoham
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sheila Nirenberg, Chethan Pandarinath
Nov 13, 2012·Nature Methods·Adam M PackerRafael Yuste
Jan 1, 2012·Translational Vision Science & Technology·Adi SchejterShy Shoham

❮ Previous
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May 30, 2014·International Journal of Nanomedicine·Lilach Bareket-Keren, Yael Hanein
Aug 8, 2014·Visual Neuroscience·John Martin BarrettPatrick Degenaar
Jun 2, 2015·Optics Letters·Sarmishtha SatpathySamarendra K Mohanty
Mar 12, 2016·Cell·Talia N LernerKarl Deisseroth
Jun 21, 2013·Biology of the Cell·Eirini Papagiakoumou
Jun 19, 2013·Journal of Physiology, Paris·Ariel TankusShy Shoham
Dec 22, 2014·Current Opinion in Neurobiology·Joshua H SiegleJakob Voigts
May 12, 2015·Médecine sciences : M/S·Marie VandecasteeleGuillaume P Dugué
Apr 10, 2015·Neuron·Elizabeth J O HamelMark J Schnitzer
Mar 19, 2015·Frontiers in Neuroengineering·Benjamin W AvantsJacob T Robinson
Dec 17, 2014·Journal of Neuroscience Methods·Serena Bovetti, Tommaso Fellin
May 31, 2016·Progress in Retinal and Eye Research·Lan YueMark S Humayun
Jul 2, 2016·Scientific Reports·David C Schedl, Oliver Bimber
Nov 2, 2016·Frontiers in Cellular Neuroscience·Rossella ContiValentina Emiliani
Feb 18, 2017·IEEE Transactions on Biomedical Circuits and Systems·Ahmed SoltanPatrick Degenaar
Feb 6, 2017·Journal of Neural Engineering·Archana JalligampalaDaniel L Rathbun
Oct 13, 2018·Journal of Biophotonics·Chenfei HuGabriel Popescu
Aug 2, 2013·Journal of Neural Engineering·Nairouz FarahShy Shoham
Aug 10, 2016·Reports on Progress in Physics·G A Goetz, D V Palanker
Jun 6, 2017·The Journal of Clinical Investigation·Laura LaprellRussell N Van Gelder
Aug 19, 2017·Journal of Neural Engineering·Y WeisslerS Shoham
Nov 24, 2015·Annual Review of Vision Science·Zhuo-Hua PanGary W Abrams
Jun 27, 2019·Biochemistry. Biokhimii︠a︡·M A Ostrovsky, M P Kirpichnikov
Mar 7, 2020·Frontiers in Neuroscience·Alexander Farnum, Galit Pelled
Aug 28, 2015·Vestnik oftalmologii·M P Kirpichnikov, M A Ostrovskiy
Sep 21, 2013·Journal of Neural Engineering·G A GoetzT Čižmár
Aug 17, 2016·Journal of Neural Engineering·Sohmyung HaGert Cauwenberghs
Jan 11, 2019·Nature Communications·Maysamreza ChamanzarMichel M Maharbiz
May 7, 2016·Journal of Neural Engineering·Omer NaorShy Shoham
Jan 1, 2016·Light, Science & Applications·Adi Schejter Bar-NoamShy Shoham
Feb 1, 2017·Advanced Biosystems·Arman AhnoodSteven Prawer
Jun 9, 2017·Annual Review of Chemical and Biomolecular Engineering·Nicole A RepinaRavi S Kane
Oct 18, 2020·Micromachines·Pei-An LoLan Yue
Nov 17, 2020·Frontiers in Molecular Neuroscience·Francesco Gobbo, Antonino Cattaneo
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