Holoprosencephaly: antenatal and postnatal diagnosis and outcome

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Chandrasekaran KaliaperumalDarach Crimmins

Abstract

The objectives of this study are to ascertain the clinical outcome and overall survival of holoprosencephaly (HPE) patients diagnosed antenatally and postnatally, to determine the accuracy of antenatal diagnosis and to determine the role of neurosurgical intervention in HPE. This is a retrospective review over a 10-year period. Sixty-three patients were included in the study, 45 were diagnosed by antenatal radiological imaging and 18 were diagnosed by postnatal radiological imaging. Patient data was drawn from Temple Street Children's University Hospital (the national paediatric neurosurgery centre), the National Maternity Hospital in Holle's Street, Dublin, and Our Lady of Sick Children Hospital, Dublin. The study was carried out through a review of antenatal and postnatal radiological imaging and reports, clinical charts, GP letters from patient follow-up and telephone conversations with parents of HPE patients. Four patients in the antenatal diagnosis group had follow-up foetal MRI confirming HPE. Twelve in this group had radiological follow-up postnatally, and in five of these, HPE was confirmed. The remaining seven were identified as false positive. Alobar HPE constituted 55 % (21/38) of patients with 95 % mortality. Fifty...Continue Reading

References

Jan 1, 1990·AJR. American Journal of Roentgenology·J P McGahanL A Mack
Oct 3, 1985·The New England Journal of Medicine·E J LammerI T Lott
Apr 1, 1983·The Journal of Pediatrics·M BarrG N Wilson
Jul 1, 1996·Journal of Medical Genetics·M L Whiteford, J L Tolmie
Aug 23, 1996·American Journal of Medical Genetics·L A CroenE J Lammer
Dec 18, 1996·American Journal of Medical Genetics·S A RasmussenJ F Cordero
Dec 31, 1997·American Journal of Medical Genetics·C L OlsenM Sharpe-Stimac
Jun 20, 1998·Pediatric Radiology·P C SonigoF O Brunelle
Apr 12, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·I M Orioli, E E Castilla
Apr 9, 2004·The New England Journal of Medicine·Robin J Edison, Maximilian Muenke
Jun 24, 2004·American Journal of Medical Genetics. Part a·Elaine E StashinkoEric B Levey
Jul 13, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Waldo SepulvedaCecilia Be
Mar 1, 2006·Brain & Development·Jin S HahnNancy J Clegg
Dec 22, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Mi Suk KimBernard Benoit
Aug 1, 2008·Annals of Neurology·Michael D GeschwindBruce L Miller
Apr 9, 2009·American Journal of Medical Genetics. Part a·Benjamin D SolomonMaximilian Muenke
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Eric A MillerUNKNOWN National Birth Defects Prevention Study
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Iêda M Orioli, Eduardo E Castilla
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jin S Hahn, Patrick D Barnes
Jan 28, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Eric B LeveyMauricio R Delgado
Sep 24, 2011·Journal of Medical Genetics·Sandra MercierSylvie Odent

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Citations

Aug 18, 2017·The Journal of Obstetrics and Gynaecology Research·Mamoru MorikawaHisanori Minakami
Jun 20, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Monica S ArroyoCharu Venkatesan

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