Holter-guided identification of premature ventricular contractions susceptible to suppression by beta-blockers

American Heart Journal
M V PitzalisP Rizzon

Abstract

To evaluate whether the identification of the different types of relations between premature ventricular contractions (PVCs) and the preceding sinus cycle length is capable of predicting the effect of beta-blockers on the PVCs themselves, 55 patients (43 men, 12 women, mean age 52.6 +/- 15.6 years) with different cardiac diseases, and >30 PVCs/hr characterized by stability and the same relation at two Holter monitoring periods were studied. The relation was tachycardia enhanced (the shorter the preceding cycle length, the higher the incidence of PVCs) in 23 patients (group 1); indifferent (no correlation between the preceding cycle length and PVC incidence) in 21 (group 2); and bradycardia enhanced (the longer the preceding cycle length, the higher the incidence of PVCs) in 11 (group 3). A third Holter monitoring was performed 6 days after nadolol administration (80 mg/day) to evaluate its effect on the three types of PVCs. Incidence in all patients (-88;p<0.001). In group 2, it caused a reduction in the majority of patients (-60%;p<0.05) but an increase in five. In group 3, it caused a reduction in only half of the patients (-45%) and a 91% increase in the remainder. The difference in the effect of nadolol in the three groups ...Continue Reading

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Citations

Jan 1, 2013·Journal of Cardiac Failure·Taibo ChenFei Lü
Jun 27, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Gregory EngelVictor F Froelicher
Feb 11, 1998·Computers and Biomedical Research, an International Journal·D SapoznikovM S Gotsman
May 17, 2017·Critical Pathways in Cardiology·Esseim SharmaAbhishek Maan
Apr 10, 2019·Journal of Cardiovascular Electrophysiology·David HamonJason S Bradfield

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