Home-based aerobic exercise in patients with lacunar stroke: Design of the HITPALS randomized controlled trial

Contemporary Clinical Trials Communications
Rikke Steen KrawcykChristina Kruuse

Abstract

The effects of physical exercise in patients with lacunar stroke, seem promising in secondary prevention and only few studies have investigated the effect of high-intensity interval training in patients with lacunar stroke. This study will be investigating whether high-intensity interval training improves cardiovascular fitness as well as cognitive- and endothelial function and potentially attenuating the risk of recurrent stroke. A randomized controlled trial evaluating 12 weeks of home-based, high-intensity interval training compared with usual care. The intervention group will be exercising 15 min a day, 5 days a week, for 12 weeks. Outcomes will be evaluated at baseline, three, six and twelve months post-stroke with 'The Graded Cycling Test with Talk Test' as the primary outcome registered as power output in Watts. Additionally, an annually register-based follow-up will be performed for 5 years from date of inclusion with a composite endpoint of cardiovascular disease or death. Secondary outcomes will be: physical activity, endothelial response, mental well-being, cognition, mood, fatigue, stress, and MRI scan. This study is going to show if early initiated home-based high-intensity interval training is feasible and effecti...Continue Reading

Citations

Mar 21, 2020·The Cochrane Database of Systematic Reviews·David H SaundersGillian E Mead
May 13, 2020·Journal of Neurochemistry·Guilherme B de FreitasFernanda G De Felice

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