Home-based tuberculosis contact investigation in Uganda: a household randomised trial

ERJ Open Research
J Lucian DavisAchilles Katamba

Abstract

The World Health Organization (WHO) recommends household tuberculosis (TB) contact investigation in low-income countries, but most contacts do not complete a full clinical and laboratory evaluation. We performed a randomised trial of home-based, SMS-facilitated, household TB contact investigation in Kampala, Uganda. Community health workers (CHWs) visited homes of index patients with pulmonary TB to screen household contacts for TB. Entire households were randomly allocated to clinic (standard-of-care) or home (intervention) evaluation. In the intervention arm, CHWs offered HIV testing to adults; collected sputum from symptomatic contacts and persons living with HIV (PLWHs) if ≥5 years; and transported sputum for microbiologic testing. CHWs referred PLWHs, children <5 years, and anyone unable to complete sputum testing to clinic. Sputum testing results and/or follow-up instructions were returned by automated SMS texts. The primary outcome was completion of a full TB evaluation within 14 days; secondary outcomes were TB and HIV diagnoses and treatments among screened contacts. There were 471 contacts of 190 index patients allocated to the intervention and 448 contacts of 182 index patients allocated to the standard-of-care. CHWs...Continue Reading

References

Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Jlucian DavisAdithya Cattamanchi
Nov 29, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·T J HwangM Uplekar
Sep 1, 2012·The European Respiratory Journal·Gregory J FoxGuy B Marks
Dec 7, 2013·The Cochrane Database of Systematic Reviews·Ipek Gurol-UrganciJosip Car
Feb 17, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E FairP C Hopewell
Jun 19, 2015·The American Journal of Medicine·David S WaldJonathan P Bestwick
Oct 31, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danielle CazabonMadhukar Pai
Jan 13, 2018·The European Respiratory Journal·Brian Kermu NgwatuUNKNOWN Collaborative group on the impact of digital technologies on TB
Jan 18, 2018·The New England Journal of Medicine·Greg J FoxGuy B Marks
Jan 31, 2018·Journal of the International AIDS Society·Adrienne E ShapiroRuanne V Barnabas
Apr 18, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J M GgitaJ L Davis
Jun 20, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K FloydM Raviglione
Sep 22, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M Armstrong-HoughJ L Davis
Nov 22, 2018·JMIR MHealth and UHealth·Amanda J MeyerJ Lucian Davis

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