Home-cage hypoactivity in mouse genetic models of autism spectrum disorder

Neurobiology of Learning and Memory
Christopher C AngelakosTed Abel

Abstract

Genome-wide association and whole exome sequencing studies from Autism Spectrum Disorder (ASD) patient populations have implicated numerous risk factor genes whose mutation or deletion results in significantly increased incidence of ASD. Behavioral studies of monogenic mutant mouse models of ASD-associated genes have been useful for identifying aberrant neural circuitry. However, behavioral results often differ from lab to lab, and studies incorporating both males and females are often not performed despite the significant sex-bias of ASD. In this study, we sought to investigate the simple, passive behavior of home-cage activity monitoring across multiple 24-h days in four different monogenic mouse models of ASD: Shank3b-/-, Cntnap2-/-, Pcdh10+/-, and Fmr1 knockout mice. Relative to sex-matched wildtype (WT) littermates, we discovered significant home-cage hypoactivity, particularly in the dark (active) phase of the light/dark cycle, in male mice of all four ASD-associated transgenic models. For Cntnap2-/- and Pcdh10+/- mice, these activity alterations were sex-specific, as female mice did not exhibit home-cage activity differences relative to sex-matched WT controls. These home-cage hypoactivity alterations differ from activit...Continue Reading

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Citations

Dec 20, 2020·Neurobiology of Learning and Memory·Sarah L FerriTed Abel
Jan 6, 2021·Brain Sciences·Rachel Michelle SaréCarolyn Beebe Smith
Oct 31, 2020·BMC Biology·Snehajyoti ChatterjeeTed Abel
Jul 17, 2021·Frontiers in Molecular Neuroscience·Elzbieta ZieminskaJerzy W Lazarewicz

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