Home orthostatic training in chronic fatigue syndrome--a randomized, placebo-controlled feasibility study.

European Journal of Clinical Investigation
K SutcliffeJulia L Newton

Abstract

Orthostatic (Tilt)-training is an effective treatment for neurally mediated hypotension (NMH). NMH is a frequent finding in chronic fatigue syndrome (CFS). We evaluated home orthostatic training (HOT) in CFS in a randomized placebo-controlled feasibility study. Thirty-eight patients with CFS (Fukuda Criteria) were randomly allocated to daily tilt training (n = 19) or sham training (n = 19) for 6 months. Haemodynamic responses to standing were performed in all subjects using continuous technology (Taskforce) at enrolment, week 1, 4 and 24. Symptom response and compliance were assessed using diaries. Two patients (one from each arm) withdrew from the study. Fourteen patients in each group complied completely or partially, and patients found the training manageable and achievable. Compared to the sham group, blood pressure while standing dropped to 8.0 mmHg less in the HOT group at 4 weeks (95% CI: 1.0 to 15.0, P = 0.03). At 4 weeks, the HOT group had higher total peripheral resistance compared to the sham group; mean difference 70.2, 95% CI: -371.4 to 511.8. Changes were maintained at 6 months. There was no significant difference in fatigue between groups at 4 weeks (mean difference 1.4, 95% CI: -13.5 to 16.2), but there was a tr...Continue Reading

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Citations

Jun 11, 2010·QJM : Monthly Journal of the Association of Physicians·A CostiganJ L Newton
Feb 13, 2013·European Journal of Clinical Investigation·Ieuan LewisJulia L Newton
Apr 21, 2016·Rheumatology·Inge De WandeleFransiska Malfait
Jan 5, 2017·British Journal of Pharmacology·Jesus Castro-MarreroJose Alegre
Jan 9, 2010·European Journal of Clinical Investigation·J P A IoannidisF B Karassa
May 20, 2011·European Journal of Gastroenterology & Hepatology·Julia L NewtonDavid E J Jones
Mar 18, 2015·Topics in Stroke Rehabilitation·Mohanasuntharaam Nadarajah, Hui-Ting Goh

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