Home parenteral nutrition and vitamin B12 status

Nutrition
D LambertJ L Guéant

Abstract

The vitamin B12 status of 20 subjects who were on home parenteral nutrition after surgical or functional small bowel resection and were given 1000 micrograms cyanocobalamin every 3 mo was studied by comparing their plasma vitamin B12, homocysteine (HS), and methylmalonic acid (MMA) concentrations. The plasma vitamin B12 concentration (median 145 pmol/L, 95% confidence interval: 123-217) was subnormal in four cases and borderline in four others. In the "4low B12" group, the concentrations of the markers of vitamin B12 deficiency were in the normal range; HS 10.7 mumol/L (8.0-12.3); and MMA, 0.15 mumol/L (0.09-0.19). References values were HS, 10.0 mumol/L (9.4-12.6); and MMA, 0.16 mumol/L (0.10-0.19). Thus, there were no metabolic signs of vitamin B12 deficiency in these subjects on parenteral nutrition, despite the fact that their plasma vitamin B12 levels were low. Analysis of individual data showed that the four patients with low circulating B12 had markers of intracellular vitamin B12 deficiency in the normal range.

Citations

Jan 7, 1998·Protein Science : a Publication of the Protein Society·D M Hoover, M L Ludwig
Jul 25, 2000·Nutrition·J E AlpertM Fava
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·V Colomb
Jan 1, 2009·Dose-response : a Publication of International Hormesis Society·Daniel P Hayes
Mar 1, 2010·Nutrients·Fiona O'Leary, Samir Samman

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