Abstract
The purpose of this study was to investigate the effects of home remodeling and food allergy (FA) on the development of atopic dermatitis (AD) in children. The Modified International Study of Asthma and Allergies in Childhood questionnaire was used to survey 4,111 children recruited from 3 kindergartens and 6 elementary schools from Seongnam, Korea. Participants' parents agreed for them to participate in physical examinations, skin prick tests, and blood tests. Home remodeling in the past 12 months (adjusted odds ratio [aOR] 3.40, P = 0.006), lifetime diagnosis of FA (aOR 3.95, P < 0.001), parental history of AD (aOR 2.67, P = 0.001), and FA (aOR 2.35, P = 0.004) were independent risk factors for lifetime diagnosis of AD ever. When history of home remodeling and FA were combined, the risk for moderate-to-severe AD by scoring atopic dermatitis (SCORAD) score increased (aOR, 7.19, P = 0.011, P for interaction = 0.034). Home remodeling, lifetime diagnosis of FA, parental history of AD, and parental history of FA were independent risk factors for AD. In addition, we observed a synergistic interaction between home remodeling and FA in the risk of moderate-to-severe AD.
References
Feb 4, 1998·The Journal of Allergy and Clinical Immunology·B Eberlein-KönigJ Ring
Sep 18, 2001·Acta Dermato-venereologica·M BöhmeC F Wahlgren
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Huss-MarpH Behrendt
Jun 19, 2007·Allergy·T WerfelM Worm
Jun 19, 2007·International Journal of Hygiene and Environmental Health·Bing-Ling WangKeiki Ogino
Jul 31, 2007·Indoor Air·M J Mendell
Aug 24, 2007·The British Journal of Dermatology·A P OranjeF B de Waard-van der Spek
Dec 11, 2007·The British Journal of Dermatology·D G PeroniA L Boner
Dec 25, 2007·The Journal of Allergy and Clinical Immunology·Hywel WilliamsUNKNOWN International Study of Asthma and Allergies in Childhood (ISAAC) Phase One and Three Study Groups
Sep 18, 2008·Acta Paediatrica·Kam-Lun Ellis HonPak-Cheung Ng
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Robert G Hamilton
Dec 8, 2010·The Journal of Allergy and Clinical Immunology·Joshua A BoyceUNKNOWN NIAID-Sponsored Expert Panel
Oct 14, 2011·The New England Journal of Medicine·Alan D IrvineDonald Y M Leung
Jul 23, 2013·The Journal of Investigative Dermatology·Carsten FlohrGideon Lack
Sep 5, 2013·Annals of Dermatology·Hye One KimChun Wook Park
Oct 16, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ivy Shiue
Oct 7, 2014·Indian Journal of Dermatology·Jarmila Celakovská, Josef Bukač
Nov 7, 2014·Allergy, Asthma & Immunology Research·Jung Hyun LeeKangmo Ahn
Dec 3, 2014·Environmental Research·I-Jen Wang, Wilfried Joachim Jurgen Karmaus
Dec 5, 2014·Annals of Dermatology·Jung Im NaChang Hun Huh
Jun 25, 2015·Allergy and Asthma Proceedings·Iwona StelmachWojciech Hanke
Aug 19, 2016·The British Journal of Dermatology·J KimK Ahn
Dec 10, 2016·The Journal of Allergy and Clinical Immunology·Robert A Wood
Dec 13, 2016·International Journal of Environmental Research and Public Health·JaKyoung KimJeong Hee Kim
Dec 23, 2016·PloS One·Rafael Taeho HanHeung Sik Na
Jan 20, 2017·Allergy, Asthma & Immunology Research·Howard ChuKwang Hoon Lee
Mar 16, 2017·Allergy, Asthma & Immunology Research·Seung Jin LeeMan Yong Han