Home versus hospital immunoglobulin treatment for autoimmune neuropathies: A cost minimization analysis

Brain and Behavior
Gwendal Le MassonIsabelle Durand-Zaleski

Abstract

Prior clinical trials have suggested that home-based Ig treatment in multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and its variant Lewis-Sumner syndrome (LSS) is safe and effective and is less costly than hospital-administered intravenous immunoglobulin (IVIg). A French prospective, dual-center, cost minimization analysis was carried out to evaluate IVIg administration (5% concentrated) at home versus in hospital with regard to costs, patients' autonomy, and patients' quality of life. The primary endpoint was the overall cost of treatment, and we adopted the perspective of the payer (French Social Health Insurance). Twenty-four patients aged 52.3 (12.2) years were analyzed: nine patients with MMN, eight with CIDP, and seven with LSS. IVIg (g/kg) dosage was 1.51 ± 0.43 in hospital and 1.52 ± 0.4 at home. Nine-month total costs per patient extrapolated to 1 year of treatment were €48,189 ± 26,105 versus €91,798 ± 51,125 in the home and hospital groups, respectively (p < .0001). The most frequently reported factors for choosing home treatment were the good tolerance and absence of side effects of IVIg administration, as well as a good understanding of the advantages and draw...Continue Reading

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Jul 26, 2018·Current Opinion in Neurology·Pietro E Doneddu, Eduardo Nobile-Orazio
Oct 24, 2018·PloS One·Victoria DivinoGirishanthy Krishnarajah
Nov 7, 2019·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Susan BauerSheryl Chan
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Apr 9, 2021·Frontiers in Neurology·Richard K BurtBasil Sharrack

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