Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction

Molecular Human Reproduction
P MurthiB Kalionis

Abstract

Fetal growth restriction (FGR) is a clinically significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. This study involved idiopathic FGR, which is frequently associated with placental dysfunction. Here, we investigated mRNA levels of the human placental homeobox gene ESX1L in pre-term and term idiopathic FGR pregnancies compared with gestation-matched controls. Real-time PCR quantitation showed ESX1L levels in control placentae decreased between pre-term and term [0.7 +/- 0.20 (27-35 weeks, n = 13) versus 0.2 +/- 0.06 (36-41 weeks, n = 12), t-test, P < 0.005]. ESX1L levels in FGR-affected placentae were significantly lower than in gestation-matched controls, and there was no significant change between pre-term FGR and term FGR [0.32 +/- 0.04 (27-36 weeks, n = 11) versus 0.31 +/- 0.02 (36-41 weeks, n = 14), t-test, P = 0.82]. Multiple linear regression analysis revealed a rapid decline in ESX1L expression in control placentae [0.075-fold of the calibrator for each week of gestation (95% CI = -0.105 to -0.045, P < 0.0005)]. In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, and the decline in ESX1L levels with gestation was not significant [0.001-...Continue Reading

Citations

Nov 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amy ChuiPadma Murthi
Feb 10, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaPradeep Sharma
Feb 27, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T P H NguyenP Murthi
May 7, 2011·Journal of Pregnancy·Padma MurthiBill Kalionis
Jan 1, 2011·Clinical Epigenetics·L Serman, D Dodig
Aug 22, 2012·Fetal Diagnosis and Therapy·Padma MurthiFabricio Da Silva Costa
Oct 11, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaSweta Shastri
Dec 8, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Nicola YuenPadma Murthi
Aug 26, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Claire R QuilterDavid B Dunger
Jun 26, 2007·Human Molecular Genetics·Xiaoxia Wang, Jianzhi Zhang

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