Homeobox genes: a molecular link between development and cancer

Pesquisa odontológica brasileira = Brazilian oral research
Fabio Daumas NunesSuzana Cantanhede de Sousa

Abstract

Homeobox genes are regulatory genes encoding nuclear proteins that act as transcription factors, regulating aspects of morphogenesis and cell differentiation during normal embryonic development of several animals. Vertebrate homeobox genes can be divided in two subfamilies: clustered, or HOX genes, and nonclustered, or divergent, homeobox genes. During the last decades, several homeobox genes, clustered and nonclustered ones, were identified in normal tissue, in malignant cells, and in different diseases and metabolic alterations. Homeobox genes are involved in the normal teeth development and in familial teeth agenesis. Normal development and cancer have a great deal in common, as both processes involve shifts between cell proliferation and differentiation. The literature is accumulating evidences that homeobox genes play an important role in oncogenesis. Many cancers exhibit expression of or alteration in homeobox genes. Those include leukemias, colon, skin, prostate, breast and ovarian cancers, among others. This review is aimed at introducing readers to some of the homeobox family functions in normal tissues and especially in cancer.

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Oct 1, 1990·Trends in Genetics : TIG·W J GehringK Wüthrich
Jan 1, 1995·Connective Tissue Research·P Sharpe
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G De VitaClemente Cillo
Jul 1, 1993·The Journal of Investigative Dermatology·G A Scott, L A Goldsmith
May 1, 1996·Stem Cells·H J LawrenceC Largman
Sep 1, 1996·Molecular and Cellular Biology·Alessandra CarèM P Colombo
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D T WongR B Donoff
Mar 27, 1997·Biochemical and Biophysical Research Communications·B Z ViderA Gazit
Oct 6, 1997·Pediatric Research·M MarkP Chambon
Aug 15, 1998·Biochemical and Biophysical Research Communications·P Y ChangN Huh
Mar 30, 1999·Experimental Cell Research·Clemente CilloE Boncinelli
May 18, 1999·Cell Biology International·H L Ford
Mar 23, 2000·Cancer Metastasis Reviews·C Caldas, S Aparicio
Feb 24, 2001·Clinical Genetics·F R Goodman, P J Scambler
Mar 10, 2001·The American Journal of Pathology·H A GolponN F Voelkel
Apr 13, 2001·Seminars in Reproductive Medicine·H S Taylor
May 9, 2001·International Reviews of Immunology·S L NuttM Busslinger
Jun 26, 2001·Journal of Cellular Physiology·Clemente CilloE Boncinelli
Aug 23, 2001·The Journal of Surgical Research·L A UyenoN Boudreau
Oct 24, 2002·Biochimica Et Biophysica Acta·Sang-Wan KimYoung-Choon Lee

Citations

Mar 19, 2004·Pathology Oncology Research : POR·Károly Méhes, György Kosztolányi
Oct 27, 2012·Breast Cancer Research and Treatment·Mohammad R AkbariCezary Cybulski
Dec 29, 2007·Medical Oncology·Deanna S Cross, J K Burmester
Nov 16, 2011·Molecular and Cellular Biology·Peck Yean TanEdwin Cheung
Jun 23, 2010·BMC Evolutionary Biology·Guang Li, Peter W H Holland
May 16, 2012·Journal of Translational Medicine·Monica CantileGerardo Botti
Nov 6, 2013·International Journal of Molecular Sciences·Monica CantileGerardo Botti
Jun 21, 2011·Journal of Thyroid Research·Shioko Kimura
Jan 3, 2009·International Journal of Biological Sciences·Yongchun SongSidney W Fu
Mar 20, 2014·Diagnostic Pathology·Rui ZhangGuoqiang Zhao
Jan 13, 2016·Prostate Cancer and Prostatic Diseases·P H C MendesH Martelli Júnior
Jul 3, 2015·Molecular Medicine Reports·Rui MaCong-Yao Lin
Jan 22, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sumei ShaKaichun Wu
Sep 5, 2006·Human Pathology·Mehsati HerawiJonathan I Epstein
Oct 9, 2013·Biochemical and Biophysical Research Communications·Yu ZhangPeter C K Leung
Feb 5, 2008·The Journal of the American Dental Association·Leigh A ChalothornSusan C Modesitt
Dec 17, 2014·Oral Oncology·Tatiana N Libório-KimuraEdward K L Chan
May 10, 2011·Journal of Applied Oral Science : Revista FOB·Renata TucciFabio Daumas Nunes
Dec 17, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Bin LiYouji Feng
Aug 5, 2005·Human Molecular Genetics·Jinbin ZhaiWilliam W Schlaepfer
Nov 19, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saravana Mohan DhanasekaranArul M Chinnaiyan
May 7, 2011·Journal of Pregnancy·Padma MurthiBill Kalionis
Dec 31, 2014·Molecular Cancer Research : MCR·Hélène BonIan G Mills

Related Concepts

Homeo Box Sequence
Malignant Neoplasms
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Developmental

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.