Homeobox genes and hematopoiesis: an emerging picture for genomic therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Homeobox genes and hematopoiesis: an emerging picture for genomic therapy

Abstract

References

Lineage and stage specific expression of HOX 1 genes in the human hematopoietic system

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells

Coordinate regulation of HOX genes in human hematopoietic cells

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

Hox and HOM: homologous gene clusters in insects and vertebrates

Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines

Homeo boxes in the study of development.

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice.

Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

Evolution of Hox genes

Hox genes in vertebrate development

A promiscuous oncogene in acute leukemia

The role of HOX homeobox genes in normal and leukemic hematopoiesis

Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements

Oncogenic transcription factors in the human acute leukemias

Effects of HOX homeobox genes in blood cell differentiation

Hox homeobox genes as regulators of normal and leukemic hematopoiesis

The role of homeobox genes in hematopoiesis

Citations

Converging pathways in leukemogenesis and stem cell self-renewal

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