Homeobox genes exhibit evolutionary conserved regionalization in the central nervous system of an ascidian larva

Zoological Science
Y KatsuyamaHidetoshi Saiga

Abstract

Animals in each subgroup of the phylum Chordata exhibit a similar process by which they form a tubular central nervous system (CNS). However, little is known about spatial relationship among the CNSs of chordates; vertebrates, cephalochordates and urochordates (tunicates). Ascidians constitute a major animal group in the subphylum Urochordata. In the present study, we examined the expression patterns of labial and orthodenticle related genes of the ascidian, Halocynthia roretzi, in the developing larval CNS. These homeobox genes exhibited region-specific expression patterns that are strikingly similar to those of murine Hoxb-1 and Otx2. The regionalization as characterized by the expression of these genes supports the division of the ascidian larval CNS suggested by the previous morphological studies. Furthermore, conservation of the expression pattern of the homeobox genes suggests that such regionalization occurred in the CNS of a putative common ancestor of chordates.

References

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Citations

Aug 31, 2000·Biochemical and Biophysical Research Communications·H NagahoraY Okamura
Mar 30, 2002·Brain Research Bulletin·Rudolf Nieuwenhuys
Oct 6, 1999·Current Opinion in Neurobiology·L Z Holland, N D Holland
Sep 4, 1998·Development, Growth & Differentiation·Y Katsuyama, H Saiga
Apr 12, 2002·Developmental Biology·You KatsuyamaYasushi Okamura
Sep 10, 1999·Developmental Biology·Y KatsuyamaH Saiga
Feb 1, 2005·Developmental Biology·Yu KatsuyamaYasushi Okamura
Aug 11, 1999·The Journal of Comparative Neurology·L ManniP Burighel
Apr 18, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Izumi Oda-Ishii, Hidetoshi Saiga
Aug 29, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lucia Manni, Paolo Burighel

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Methods Mentioned

BETA
PCR

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