Homeodomain-DNA recognition

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Homeodomain-DNA recognition

Abstract

References

Homeobox genes and axial patterning

Twin of I-POU: a two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

Mapping functional specificity in the Dfd and Ubx homeo domains

In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster

Transcription factors: structural families and principles of DNA recognition

Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene

Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements.

A genetic model for interaction of the homeodomain recognition helix with DNA.

Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA.

I-POU: a POU-domain protein that inhibits neuron-specific gene activation.

Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity

Transcriptional regulation of liver-specific gene expression

DNA binding specificity of homeodomains.

The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif

Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

DNA binding properties of the purified Antennapedia homeodomain

The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated.

Binding of yeast a1 and alpha 2 as a heterodimer to the operator DNA of a haploid-specific gene.

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.

The structure of the homeodomain and its functional implications.

Similarities between the homeodomain and the Hin recombinase DNA-binding domain.

Functional dissection of Ultrabithorax proteins in D. melanogaster

Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast

Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy

Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase

Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

The structure and function of the homeodomain

A single amino acid can determine the DNA binding specificity of homeodomain proteins

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors

A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes

Homeo boxes in the study of development.

Regulation and function of the Drosophila segmentation gene fushi tarazu.

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

Synthesis of a sequence-specific DNA-cleaving peptide

The yeast cell-type-specific repressor alpha 2 acts cooperatively with a non-cell-type-specific protein

Crystal structure of trp repressor/operator complex at atomic resolution

A universal target sequence is bound in vitro by diverse homeodomains

Nuclear magnetic resonance spectroscopy of a DNA complex with the uniformly 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain

Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex

Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain

Homeodomain proteins

The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1

Citations

Target gene identification: target specific transcriptional activation by three murine homeodomain/VP16 hybrid proteins in Saccharomyces cerevisiae

Tissue-specific expression of murine Nkx3.1 in the male urogenital system

An evolutionary conserved element is essential for somite and adjacent mesenchymal expression of the Hoxa1 gene

Protein-DNA recognition complexes: conservation of structure and binding energy in the transition state.

Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells

Effects of HOX homeobox genes in blood cell differentiation

Analysis of murine HOXA-2 activity in Drosophila melanogaster

Plant homeobox genes: many functions stem from a common motif

Target genes of homeodomain proteins

Distal-less function during Drosophila appendage and sense organ development

The specificity of homeotic gene function

Homeosis and polyposis: a tale from the mouse

Drosophila engrailed-1,10-phenanthroline chimeras as probes of homeodomain-DNA complexes

Homology modeling using simulated annealing of restrained molecular dynamics and conformational search calculations with CONGEN: application in predicting the three-dimensional structure of murine homeodomain Msx-1

Cloning and expression of Munc 30: a member of the paired -like homeodomain gene family

The role of homeobox genes in hematopoiesis

Brassica GLABRA2 genes: analysis of function related to seed oil content and development of functional markers.

Cloning and characterization of an HDZip I gene GmHZ1 from soybean

Structure, regulation, and function of micro1 in the sea urchin Hemicentrotus pulcherrimus

Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster

Homeodomain revisited: a lesson from disease-causing mutations

Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations.

Hox genes and their candidate downstream targets in the developing central nervous system

Assembly of the Tc1 and mariner transposition initiation complexes depends on the origins of their transposase DNA binding domains

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives

A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses