PMID: 3772375Dec 1, 1986Paper

Homeostasis of brain and cerebrospinal fluid calcium concentrations during chronic hypo- and hypercalcemia

Journal of Neurochemistry
V A MurphyS I Rapoport

Abstract

Three-week-old rats were made hypocalcemic or hypercalcemic by being fed diets low or high in Ca. Both total and ionized [Ca]s in the plasma decreased about 40% and remained depressed for 4 weeks in rats fed a low-Ca diet. Plasma [Ca]s in rats fed a high-Ca diet increased by 30% and remained elevated for 7 weeks. After 8 weeks on the diets, cerebrospinal fluid (CSF) [Ca] changed by less than 30% whereas brain [Ca] changed by less than 20% of the chronic changes in plasma ionized [Ca]. Assuming a brain extracellular volume of 20% and noting that brain extracellular volume equilibrates freely with CSF, the findings demonstrate only small perturbations in the Ca content of the brain cellular compartment during sustained hypo or hypercalcemia. Partial regulation of CSF and brain extracellular Ca suggests a role for the blood-brain barrier in regulating CNS [Ca] during chronic changes in plasma [Ca].

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Citations

Oct 1, 1991·Journal of Neuroscience Research·V A MurphyS I Rapoport
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·M PalmiG Sgaragli
Jan 1, 1991·Neurochemistry International·A TenenhouseJ W Commissiong
Jun 1, 1994·Progress in Neurobiology·K C Wadhwani, S I Rapoport
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Martial Ruat, Elisabeth Traiffort
Nov 25, 2004·Neuroscience·P D BrownI D Millar
Aug 23, 1991·Brain Research·V A MurphyS I Rapoport
Jan 10, 2012·Neuroscience Letters·Mahmoud SalamiMohsen Taghizadeh
Jul 31, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Marcus KorvelaJean Pettersson
Nov 2, 2016·Neurosurgical Focus·Jason K KarimyKristopher T Kahle
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, J K Deshpande
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E MartinsB K Siesjö
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I A Silver, M Erecińska
Oct 19, 2013·Physiological Reviews·Helle H DamkierJeppe Praetorius
Jan 3, 2001·Microscopy Research and Technique·T SpeakeP D Brown
Apr 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kubra Serefoglu CabukMuhittin Taskapili

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