Homeostasis of IL-15 dependent lymphocyte subsets in the liver

Cytokine
Yuneivy Cepero-DonatesSheela Ramanathan

Abstract

IL-15 is a member of the gamma chain family of cytokines (γc - CD132). The IL-15 receptor (IL-15R) complex consists of 3 subunits: the ligand-binding IL-15Rα chain (CD215), the β chain (CD122; also used by IL-2), and the common γ chain. The biological activities of IL-15 are mostly mediated by the IL-15:IL-15Rα complex, produced by the same cell and 'trans-presented' to responder cells expressing the IL-15Rβγc. The peculiar and almost unique requirement for IL-15 to be trans-presented by IL-15Rα suggests that the biological effects of IL-15 signaling are tightly regulated even at the level of availability of IL-15. Tissue-specific deletion of IL-15Rα has shown macrophage-and dendritic cell-derived IL-15Rα mediate the homeostasis of different CD8(+) T cell subsets. Here we show that hepatocyte and macrophage- specific expression of IL-15Rα is required to maintain the homeostasis of NK and NKT cells in the liver. Thus, homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.

References

Nov 15, 2002·Molecular Immunology·James LodolceAveril Ma
Nov 16, 2002·Immunity·Sigrid DuboisYutaka Tagaya
Apr 2, 2003·Nature Reviews. Immunology·Kimberly S Schluns, Leo Lefrançois
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark A Exley, Margaret James Koziel
May 18, 2005·The International Journal of Biochemistry & Cell Biology·Kimberly S SchlunsLeo Lefrançois
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vito Racanelli, Barbara Rehermann
Apr 11, 2007·The Journal of Experimental Medicine·Jared F PurtonCharles D Surh
Jun 26, 2007·Nature Reviews. Immunology·Dale I Godfrey, Stuart P Berzins
Mar 24, 2009·Annual Review of Immunology·Ian Nicholas Crispe
Oct 13, 2009·Immunology Letters·Spencer W Stonier, Kimberly S Schluns
Jan 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rinke StienstraMichael Müller
Nov 30, 2010·Cellular Immunology·Partha S BiswasAlessandra B Pernis
Apr 22, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva Morán-SalvadorJoan Clària
Aug 27, 2011·Nature Reviews. Immunology·Joseph C Sun, Lewis L Lanier
Oct 16, 2012·The Journal of Biological Chemistry·Annie-Carole Tosello-TrampontYoung S Hahn
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Guangwei CuiKoichi Ikuta
Jun 19, 2015·World Journal of Hepatology·Monjur Ahmed

❮ Previous
Next ❯

Citations

Mar 22, 2016·Cytokine·Subburaj Ilangumaran, Gerardo Ferbeyre
Jul 27, 2018·Canadian Journal of Gastroenterology & Hepatology·Daniel S SmykDimitrios P Bogdanos
Feb 10, 2021·Expert Review of Gastroenterology & Hepatology·Azalia Mariel Carranza-TrejoEdgar B Montufar
Apr 9, 2021·Frontiers in Immunology·Gráinne Jameson, Mark W Robinson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.