PMID: 16629164Apr 25, 2006Paper

Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination

Biological Research
Jerome A Roth

Abstract

This review attempts to summarize and clarify our basic knowledge as to the various factors that potentially influence the risks imposed from chronic exposure to high atmospheric levels of manganese (Mn). The studies describe the interrelationship of the different systems in the body that regulate Mn homeostasis by characterizing specific, biological components involved in its systemic and cellular uptake and its elimination from the body. A syndrome known as manganism occurs when individuals are exposed chronically to high levels of Mn, consisting of reduced response speed, intellectual deficits, mood changes, and compulsive behaviors in the initial stages of the disorder to more prominent and irreversible extrapyramidal dysfunction resembling Parkinson's disease upon protracted exposure. Mn intoxication is most often associated with occupations in which abnormally high atmospheric concentrations prevail, such as in welding and mining. There are three potentially important routes by which Mn in inspired air can gain access the body to: 1) direct uptake into the CNS via uptake into the olfactory or trigeminal presynaptic nerve endings located in the nasal mucosa and the subsequent retrograde axonal transport directly into the C...Continue Reading

Citations

Feb 15, 2013·Journal of Bone and Mineral Metabolism·Wang ZhaojunLiu Ran
Apr 9, 2008·Journal of Inherited Metabolic Disease·Karin TuschlPeter T Clayton
Jul 29, 2010·Journal of Exposure Science & Environmental Epidemiology·Deborah C RiceAndrew E Smith
Jun 28, 2012·The Journal of Biological Chemistry·Anthony C IllingBryan Mackenzie
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Annette B Santamaria, Sandra I Sulsky
Nov 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Jursa, Donald R Smith
Dec 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vanessa A FitsanakisMichael Aschner
Nov 17, 2009·Journal of Veterinary Internal Medicine·A G GowR J Mellanby
Sep 22, 2010·Environmental Health Perspectives·Maryse F BouchardDonna Mergler
Mar 1, 2012·PloS One·Rod D BraunBruce A Berkowitz
Jan 11, 2011·Interdisciplinary Toxicology·Ladislav Soltés, Grigorij Kogan
Aug 12, 2014·Experimental Gerontology·Miloš SunderićOlgica Nedić
Jun 5, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jean-Marc Moulis
Apr 12, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mark R Bleackley, Ross T A Macgillivray
Feb 10, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Supak JenkitkasemwongMitchell D Knutson
Dec 10, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Dalian DingJerome A Roth
Nov 11, 2009·Neuromolecular Medicine·Robert A Yokel
Dec 17, 2009·Neuromolecular Medicine·Roberto G LucchiniBrent C Doney
Mar 21, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Chibuisi G AlimbaMichael Fenech
Jan 15, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Madhu NagappaArun B Taly
Jan 15, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Michael S MadejczykNazzareno Ballatori
Aug 30, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sumitaka HasegawaTsuneo Saga
Mar 16, 2013·Molecular Nutrition & Food Research·Julia BornhorstTanja Schwerdtle
Mar 19, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Courtney J MercadanteThomas B Bartnikas
Aug 30, 2008·Brain Research·A P Marreilha dos SantosM Camila C Batoréu
Oct 15, 2013·Neurotoxicology·José A Menezes-FilhoNeander Abreu
Mar 18, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Marialuisa QuadriVincenzo Bonifati
Oct 12, 2011·Experimental Neurology·Liliana QuintanarLourdes Massieu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
Calivarathan LatchoumycandaneAnumantha G Kanthasamy
American Journal of Physiology. Lung Cellular and Molecular Physiology
Elizabeth A HeiligMarianne Wessling-Resnick
© 2022 Meta ULC. All rights reserved