Homeostatic control of dendritic cell numbers and differentiation

Immunology and Cell Biology
Regine J DressFlorent Ginhoux

Abstract

Dendritic cells (DCs) are a diverse family of cells that play a crucial role in linking our innate and adaptive immune system to initiate adequate T-cell responses. They respond to pathogens by triggering the appropriate adaptive immune response that is required to clear invaders while balancing the need to limit tissue damage as a result of inflammation. Perturbation in DC regulation results in abnormal T-cell homeostasis, leading to development of autoimmune diseases and aberrant responses to pathogens. In recent years, it has become clear that the DC family is more complex than initially thought in terms of their identification, homeostasis and functions. In this review, we discuss recent findings that improve our understanding of development, and functional specializations of conventional and plasmacytoid DCs.

References

Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T KamathK Shortman
Jan 31, 2006·Nature Immunology·Florent GinhouxMiriam Merad
Dec 16, 2006·Nature Reviews. Immunology·Ken Shortman, Shalin H Naik
Apr 24, 2007·Nature Immunology·Kang LiuMichel Nussenzweig
Feb 5, 2008·Free Radical Biology & Medicine·Annalisa Del PreteMichele Lorusso
Jul 2, 2008·The Journal of Experimental Medicine·Corine H GeurtsvanKesselBart N Lambrecht
Jul 22, 2008·Nature Reviews. Immunology·Michel GillietYong-Jun Liu
Sep 19, 2008·Immunity·José A Villadangos, Louise Young
Nov 26, 2008·Nature Reviews. Immunology·Miriam MeradMatthew Collin
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshimichi MatsuiA Karolina Palucka
Dec 17, 2009·The Journal of Experimental Medicine·Florent GinhouxMiriam Merad
Nov 16, 2011·The Journal of Experimental Medicine·Melissa SwieckiMarco Colonna
Dec 8, 2011·Journal of Leukocyte Biology·Shinji Kasahara, Edward A Clark
Aug 9, 2012·The International Journal of Biochemistry & Cell Biology·Patrizia ZaccagninoAnnalisa Del Prete
May 20, 2014·Immunity·Alexander Mildner, Steffen Jung
Jun 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qian ZhouDavid M Kemeny
Jul 2, 2014·The Journal of Experimental Medicine·Hiyaa S GhoshBoris Reizis
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Dec 24, 2014·Nature Reviews. Immunology·Edward J Pearce, Bart Everts
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Emma M CarringtonYifan Zhan
May 11, 2015·Seminars in Cell & Developmental Biology·Andreas SchlitzerFlorent Ginhoux
Jul 15, 2015·Nature Reviews. Immunology·Melissa Swiecki, Marco Colonna

❮ Previous
Next ❯

Citations

Nov 9, 2018·Frontiers in Immunology·Peter SeeFlorent Ginhoux
Jun 8, 2018·Immunology and Cell Biology·Nicholas D Huntington, Daniel Hd Gray
May 31, 2019·Frontiers in Immunology·Rajkumar NoubadeKristin V Tarbell
Nov 16, 2018·Nature Reviews. Immunology·Kenji KabashimaGyohei Egawa
Mar 21, 2020·Frontiers in Immunology·Harriet A PurvisAndrew P Cope
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Mar 7, 2020·Frontiers in Oncology·Rosalinda TrovatoFrancesco De Sanctis
Jun 14, 2019·Frontiers in Immunology·Andrea MusumeciAnne Barbara Krug

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Immunology
Sandeep Sundara Rajan, Maria Paula Longhi
Trends in Immunology
Jurjen TelI Jolanda M de Vries
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P-P CaoZ Liu
© 2022 Meta ULC. All rights reserved