PMID: 8594883Dec 1, 1995Paper

Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats

The American Journal of Physiology
V VallonS Thomson

Abstract

We tested the hypothesis that the ability of the tubuloglomerular feedback (TGF) to stabilize renal function is impaired in rats with 7-8 wk of insulin-treated streptozotocin-diabetes. Proximal tubular flow was measured in free-flowing nephrons using a noninvasive optical technique. The homeostatic efficiency of TGF was determined from the fractional compensation for perturbations in ambient flow. Fractional compensation was substantially reduced in diabetic rats. To assess the roles of the proximal tubule and loop of Henle as determinants of TGF efficiency, we tested the effect of diabetes on proximal tubular reabsorption as determined by standard micropuncture and on the ionic content of early distal tubular fluid by employing a microelectrode for on-line measurement of electrical conductivity (TED). Diabetes caused glomerular hyperfiltration and increased fractional proximal tubular reabsorption (FPR), such that late proximal tubular flow (VLP) and early distal tubular flow were unaffected. The increase in FPR was a minor contributor to the overall effect on fractional compensation. Diabetes decreased the ambient TED without affecting the slope of the relationship between VLP and TED. These results demonstrate that the homeo...Continue Reading

Citations

Dec 6, 2003·American Journal of Physiology. Renal Physiology·Scott C ThomsonRoland C Blantz
Dec 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David Z LevineGhadeer A Mokhtar
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Jun 20, 2008·American Journal of Physiology. Renal Physiology·Cynthia M MiracleScott C Thomson
Sep 23, 2009·Current Opinion in Nephrology and Hypertension·Pamela K Carmines
Jan 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volker Vallon
Sep 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Scott C ThomsonPrabhleen Singh
Aug 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas MitrouWilliam A Cupples
Jan 25, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton, Volker Vallon
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·S M Fitzgerald, M W Brands
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Scott C ThomsonFrancis B Gabbai
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Larry A SlomowitzScott C Thomson
May 18, 2006·American Journal of Physiology. Renal Physiology·Joseph SatrianoRoland C Blantz
Jan 21, 2012·American Journal of Physiology. Renal Physiology·Anita T LaytonHarold E Layton
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Robert Faulhaber-WalterJurgen Schnermann
Apr 10, 2015·American Journal of Physiology. Renal Physiology·Anita T LaytonAurélie Edwards
Sep 5, 2002·Annual Review of Physiology·Jürgen Schnermann, David Z Levine
Feb 8, 2002·American Journal of Physiology. Renal Physiology·P Scherzer, M M Popovtzer
Mar 14, 2014·American Journal of Physiology. Renal Physiology·Ioannis Sgouralis, Anita T Layton
Feb 18, 2012·Annual Review of Physiology·Volker Vallon, Scott C Thomson
Mar 11, 2000·American Journal of Physiology. Renal Physiology·V VallonM Hropot
Jul 19, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Volker Vallon
Sep 1, 2000·American Journal of Physiology. Renal Physiology·R KomersS Anderson
May 9, 2003·American Journal of Physiology. Renal Physiology·Radko Komers, Sharon Anderson
Apr 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David Z LevineSusan J Robertson
Feb 24, 2012·American Journal of Physiology. Renal Physiology·Hong WangOscar A Carretero
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Dec 25, 2008·American Journal of Physiology. Renal Physiology·Seiji HashimotoTakao Koike
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Oct 28, 2020·International Journal of Molecular Sciences·Yi-Chou HouKuo-Cheng Lu
Mar 2, 2021·American Journal of Physiology. Renal Physiology·Scott Culver Thomson, Volker Vallon

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