DOI: 10.1101/453753Oct 25, 2018Paper

Homeostatic plasticity rules control the wiring of axo-axonic synapses at the axon initial segment

BioRxiv : the Preprint Server for Biology
Alejandro Pan-VazquezJuan Burrone

Abstract

The activity-dependent rules that govern the wiring of GABAergic interneurons are not well understood. Chandelier cells (ChCs), a GABAergic interneuron, control pyramidal cell output through axo-axonic synapses that target the axon initial segment. In vivo imaging of ChCs during development uncovered a narrow window (P12-P18) over which axons arborized and formed connections. We found that increases in the activity of either pyramidal cells or individual ChCs during this temporal window results in a reversible decrease in axo-axonic connections, at a time when they are depolarising. Identical manipulations of network activity in older mice (P40-P46), when ChC synapses are inhibitory, resulted in an increase in axo-axonic synapses. We propose that the direction of ChC plasticity follows homeostatic rules that depend on the polarity of axo-axonic synapses.

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Winnie WefelmeyerJuan Burrone
Frontiers in Neuroscience
Alan R WoodruffRafael Yuste
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Melis InanRafael Yuste
© 2021 Meta ULC. All rights reserved