Homeostatic plasticity shapes the visual system's first synapse

Nature Communications
Robert E JohnsonDaniel Kerschensteiner

Abstract

Vision in dim light depends on synapses between rods and rod bipolar cells (RBCs). Here, we find that these synapses exist in multiple configurations, in which single release sites of rods are apposed by one to three postsynaptic densities (PSDs). Single RBCs often form multiple PSDs with one rod; and neighboring RBCs share ~13% of their inputs. Rod-RBC synapses develop while ~7% of RBCs undergo programmed cell death (PCD). Although PCD is common throughout the nervous system, its influences on circuit development and function are not well understood. We generate mice in which ~53 and ~93% of RBCs, respectively, are removed during development. In these mice, dendrites of the remaining RBCs expand in graded fashion independent of light-evoked input. As RBC dendrites expand, they form fewer multi-PSD contacts with rods. Electrophysiological recordings indicate that this homeostatic co-regulation of neurite and synapse development preserves retinal function in dim light.

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Citations

Jun 2, 2018·Neural Development·Nai-Wen Tien, Daniel Kerschensteiner
Mar 20, 2018·ELife·Florentina SotoDaniel Kerschensteiner
Aug 9, 2020·Stem Cells Translational Medicine·Ali E GhareebDavid H Steel
Oct 27, 2018·Frontiers in Neural Circuits·Benjamin E Reese
Apr 4, 2020·Current Biology : CB·Ning ShenDaniel Kerschensteiner

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Methods Mentioned

BETA
electron microscopy
transgenic
confocal microscopy
transgenically
PCR

Key Resources (RRID) Mentioned

MGI
IMSR_JAX
AB_2069582
AB_399431
AB_477375
AB_394264
AB_2534023
AB_2533208
AB_2534096
AB_2534069

Software Mentioned

MATLAB
custom
Amira
eMagin

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