Homeostatic regulation of excitatory synapses on striatal medium spiny neurons expressing the D2 dopamine receptor

Brain Structure & Function
Dominic ThibaultLouis-Eric Trudeau

Abstract

Striatal medium spiny neurons (MSNs) are contacted by glutamatergic axon terminals originating from cortex, thalamus and other regions. The striatum is also innervated by dopaminergic (DAergic) terminals, some of which release glutamate as a co-transmitter. Despite evidence for functional DA release at birth in the striatum, the role of DA in the establishment of striatal circuitry is unclear. In light of recent work suggesting activity-dependent homeostatic regulation of glutamatergic terminals on MSNs expressing the D2 DA receptor (D2-MSNs), we used primary co-cultures to test the hypothesis that stimulation of DA and glutamate receptors regulates the homeostasis of glutamatergic synapses on MSNs. Co-culture of D2-MSNs with mesencephalic DA neurons or with cortical neurons produced an increase in spines and functional glutamate synapses expressing VGLUT2 or VGLUT1, respectively. The density of VGLUT2-positive terminals was reduced by the conditional knockout of this gene from DA neurons. In the presence of both mesencephalic and cortical neurons, the density of synapses reached the same total, compatible with the possibility of a homeostatic mechanism capping excitatory synaptic density. Blockade of D2 receptors increased the...Continue Reading

References

Aug 1, 1997·Experimental Neurology·J J KelleyR C Roberts
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
Jun 11, 1999·Neuroscience·P RedgraveK Gurney
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R A McKinneyS M Thompson
Aug 3, 2000·Journal of Anatomy·J P BolamM D Bevan
Oct 10, 2002·The European Journal of Neuroscience·C L ParishM K Horne
Jun 26, 2003·The European Journal of Neuroscience·Menahem SegalEduard Korkotian
Mar 15, 2005·Journal of Neuroscience Methods·Xiaoxi ZhuangRené Hen
Sep 27, 2005·Neuropharmacology·Christelle GrasSalah El Mestikawy
Jan 24, 2007·The European Journal of Neuroscience·Tsuyoshi YamaguchiMarisela Morales
Feb 19, 2008·Nature Neuroscience·Christelle GrasSalah El Mestikawy
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose Alfredo MendezLouis-Eric Trudeau
Jul 18, 2008·Current Protocols in Neuroscience·Caroline FasanoLouis-Eric Trudeau
Aug 9, 2008·Science·Weixing ShenD James Surmeier
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan Moss, J Paul Bolam
Nov 4, 2008·Experimental Neurology·Rosa M VillalbaYoland Smith
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle DayD James Surmeier
Jun 16, 2009·Current Opinion in Neurobiology·Yoshihiro YoshiharaDominique Muller
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yvonne SchmitzDavid Sulzer
Oct 22, 2009·The Journal of Comparative Neurology·Noémie Bérubé-CarrièreLaurent Descarries
Oct 23, 2009·Annals of Neurology·Rogan B TinsleyMalcolm K Horne
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carolina BirgnerAsa Wallén-Mackenzie
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alice DobiMarisela Morales
Mar 4, 2010·Molecular and Cellular Neurosciences·Xinyong TianD James Surmeier
Mar 30, 2010·Annual Review of Neuroscience·Paul Cisek, John F Kalaska
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fatuel TecuapetlaTibor Koos

❮ Previous
Next ❯

Citations

Jul 10, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Luz M SuarezRosario Moratalla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.