Homeostatic scaling of excitability in recurrent neural networks.

PLoS Computational Biology
Michiel W H Remme, Wytse J Wadman

Abstract

Neurons adjust their intrinsic excitability when experiencing a persistent change in synaptic drive. This process can prevent neural activity from moving into either a quiescent state or a saturated state in the face of ongoing plasticity, and is thought to promote stability of the network in which neurons reside. However, most neurons are embedded in recurrent networks, which require a delicate balance between excitation and inhibition to maintain network stability. This balance could be disrupted when neurons independently adjust their intrinsic excitability. Here, we study the functioning of activity-dependent homeostatic scaling of intrinsic excitability (HSE) in a recurrent neural network. Using both simulations of a recurrent network consisting of excitatory and inhibitory neurons that implement HSE, and a mean-field description of adapting excitatory and inhibitory populations, we show that the stability of such adapting networks critically depends on the relationship between the adaptation time scales of both neuron populations. In a stable adapting network, HSE can keep all neurons functioning within their dynamic range, while the network is undergoing several (patho)physiologically relevant types of plasticity, such a...Continue Reading

References

Apr 1, 1989·Journal of Neurophysiology·Y Chagnac-Amitai, B W Connors
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Jan 1, 1989·Annual Review of Physiology·W N Ross
Jan 1, 1972·Biophysical Journal·H R Wilson, J D Cowan
Dec 6, 1996·Science·C van Vreeswijk, H Sompolinsky
Jan 1, 1996·Journal of Neural Transmission·J LiepertJ P Malin
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Jul 1, 1997·Neural Computation·G R Holt, C Koch
Aug 11, 1998·Neural Computation·C van Vreeswijk, H Sompolinsky
Oct 24, 1998·The European Journal of Neuroscience·D Paré, E J Lang
Jul 27, 1999·Neural Computation·J GolowaschE Marder
Aug 17, 1999·Nature Neuroscience·N S DesaiG G Turrigiano
May 16, 2000·Journal of Computational Neuroscience·N Brunel
Jan 22, 2004·Nature Reviews. Neuroscience·Gina G Turrigiano, Sacha B Nelson
Feb 6, 2004·Journal of Computational Neuroscience·Hamish MeffinDavid B Grayden
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ingrid van WelieWytse J Wadman
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Oct 16, 2004·Nature·D B ChklovskiiK Svoboda
Nov 13, 2004·The Journal of Physiology·Peter Somogyi, Thomas Klausberger
Mar 24, 2006·The European Journal of Neuroscience·Uma R Karmarkar, Dean V Buonomano
Dec 21, 2007·Nature·Arthur R Houweling, Michael Brecht
Apr 9, 2008·Physiological Reviews·P Jesper SjöströmMichael Häusser
Aug 15, 2008·Journal of Neurophysiology·Aundrea F BartleyJay R Gibson
Aug 29, 2012·Biochemical and Biophysical Research Communications·Sujeong Lee, Jeehyun Kwag

❮ Previous
Next ❯

Citations

Jan 15, 2014·Neuropharmacology·Mikael C Guzman-KarlssonJ David Sweatt
Apr 1, 2015·Neural Computation·Hazem ToutounjiGordon Pipa
Jul 15, 2015·PLoS Computational Biology·Daniel HarnackMark C W van Rossum
Aug 3, 2017·Proceedings of the National Academy of Sciences of the United States of America·Caroline A Lea-CarnallLaura M Parkes
May 31, 2017·Frontiers in Computational Neuroscience·Hafsteinn EinarssonAngelika Steger
Dec 25, 2019·Scientific Reports·Géza Ódor, Jeffrey Kelling
Mar 19, 2021·Frontiers in Computational Neuroscience·Fabian Schubert, Claudius Gros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.