Homeostatic synaptic scaling is regulated by protein SUMOylation.

The Journal of Biological Chemistry
Tim J CraigJeremy M Henley

Abstract

Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network activity with tetrodotoxin, which increases surface expression of AMPA receptors (AMPARs), dramatically reduces levels of the deSUMOylating (where SUMO is small ubiquitin-like modifier) enzyme SENP1, leading to a consequent increase in protein SUMOylation. Overexpression of the catalytic domain of SENP1 prevents this scaling effect, and we identify Arc as a SUMO substrate involved in the tetrodotoxin-induced increase in AMPAR surface expression. Thus, protein SUMOylation plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling.

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Citations

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Methods Mentioned

BETA
ubiquitination
confocal microscopy
immunoprecipitation

Software Mentioned

ImageJ
Adobe Photoshop
NIH ImageJ
COR Image Studio
LI

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