PMID: 9106166Feb 1, 1997Paper

Homeotic transformation of legs to mouthparts by proboscipedia expression in Drosophila imaginal discs

Mechanisms of Development
A C Aplin, T C Kaufman

Abstract

The Drosophila homeotic gene proboscipedia (pb) specifies labial identify and directs formation of the adult distiproboscis from the labial imaginal discs. pb null alleles result in the homeotic transformation of the distiproboscis into prothoracic (T1) legs [Kaufman (1978) Genetics 90, 579-596; Pultz et al. (1988) Genes Dev. 2, 901-920]. Homology with other transcription factors, localization to the nucleus, and restricted embryonic and imaginal expression implicate the pb protein (PB) as a transcription factor. In order to examine the possible roles that PB may play in the specification of adult mouthparts, we have expressed PB in cells of wing, leg and eye-antennal imaginal discs and assayed for effects on the development of adult structures. We report here that the ectopic expression of PB in the imaginal discs under the control of the inducible GAL4 system [Brand and Perrimon (1993) Development 118, 401-415] alters the developmental program of adult legs into maxillary or labial palps. These homeotic transformations have an equal effect on all three sets of legs, indicating an activity that is not solely dependent upon the unique combinations of other homeotic genes present in each of the leg discs. Segment polarity genes ...Continue Reading

References

Jan 24, 1992·Cell·D St Johnston, C Nüsslein-Volhard
Nov 22, 1990·Nature·A P GouldR A White
Oct 24, 1973·Nature: New Biology·A Garcia-BellidoG Morata
Jun 28, 1996·Cell·P A Lawrence, G Struhl
Mar 7, 1991·Nature·J J StuartR E Denell
Jul 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R W BeemanR E Denell

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Citations

May 14, 1999·Developmental Genetics·A Percival-Smith, J A Bondy
Oct 15, 2013·Development Genes and Evolution·Anthony Percival-SmithWendy A Teft
May 26, 1998·The EMBO Journal·J DongH M Krause
Dec 21, 2002·Evolution & Development·Cynthia L Hughes, Thomas C Kaufman
Jun 20, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Scott Barish, Pelin Cayirlioglu Volkan
Dec 29, 1998·Mechanisms of Development·I Monge, P J Mitchell
Apr 5, 2001·Mechanisms of Development·D F MillerT Kaufman
Dec 15, 2012·Mechanisms of Development·Tomonori Katsuyama, Renato Paro
Jun 3, 2004·Mechanisms of Development·Simon G SprecherFrank Hirth
Apr 15, 2006·PLoS Biology·Nicolas NègreGiacomo Cavalli
Aug 5, 2009·Current Topics in Developmental Biology·Walter J GehringHiroshi Suga
Sep 27, 2002·Genesis : the Journal of Genetics and Development·Joseph B Duffy
Jul 21, 2006·The Journal of Comparative Neurology·Andreas S ThumHiromu Tanimoto
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Sally K GallenaWei Tian
Jun 11, 2004·Genome Génome / Conseil National De Recherches Canada·I TayyabA Percival-Smith
May 24, 2019·Neuroscience Bulletin·Chao GuoZhefeng Gong
Nov 17, 2016·Development Genes and Evolution·Anthony Percival-Smith
Aug 24, 2021·Frontiers in Cell and Developmental Biology·James C-G HombríaCarlos Sánchez-Higueras

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