Homicidal ideation with intent during a manic episode triggered by antidepressant medication in a man with brain injury

Bipolar Disorders
Marie-José DealbertoLuc Bourgon

Abstract

Mood disorders are more frequent after brain injury and both depressive and manic episodes are associated in these patients with an increased risk of aggression. Antidepressant medications are associated with a risk of manic induction. We describe a case of homicidal ideation with intent during the onset of a manic episode in a patient with prior brain injury on antidepressant medication at low dosage. The manic episode could have been secondary to brain injury and/or triggered by antidepressant medications. This case raises the possibility of the sensitizing role of brain injury for antidepressant-induced mania. Further studies are needed to assess the role of brain injury as a risk factor for antidepressant-induced mania. Physicians should be cautious when prescribing antidepressants to patients with prior brain injury and inform them and their relatives of the possibility of a switch into mania.

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Citations

Feb 18, 2014·The Psychiatric Clinics of North America·Ricardo E Jorge, David B Arciniegas
Jun 24, 2016·Indian Journal of Psychological Medicine·Syed UmmarShree Aarthi Ramanathan

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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