Homing receptor expression is deviated on CD56+ blood lymphocytes during pregnancy in Type 1 diabetic women

PloS One
S D BurkePatricia D A Lima

Abstract

Type 1 Diabetes Mellitus (T1DM) is characterized by an augmented pro-inflammatory immune state. This contributes to the increased risk for gestational complications observed in T1DM mothers. In normal pregnancies, critical immunological changes occur, including the massive recruitment of lymphocytes, particularly CD56bright NK cells, into early decidua basalis and a 2nd trimester shift towards Type 2 immunity. Decidual CD56bright NK cells arise at least partly from circulating progenitors expressing adhesion molecules SELL and ITGA4 and the chemokine receptors CXCR3 and CXCR4. In vitro studies show that T1DM reduces interactions between blood CD56+ NK cells and decidual endothelial cells by reducing SELL and ITGA4-based interactions. To address the mechanisms by which specific lymphocyte subsets may be recruited from the circulation during pregnancy and whether these mechanisms are altered in T1DM, flow cytometry was used to examine eight peripheral blood lymphocyte subsets (Type 1 (IL18R1+) and Type 2 (IL1RL1+) CD56bright NK, CD56dim NK, NKT and T cells) from control and T1DM women. Blood was collected serially over pregnancy and postpartum, and lymphocytes were compared for expression of homing receptors SELL, ITGA4, CXCR3, a...Continue Reading

References

Dec 1, 1996·Journal of Reproductive Immunology·G S Vince, P M Johnson
Apr 27, 2000·Current Opinion in Immunology·J J Campbell, E C Butcher
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J CampbellE C Butcher
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·W L ChanN A Al-Ali
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sirirak ChantakruB Anne Croy
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Vlatka S TokmadzićDaniel Rukavina
Feb 15, 2003·Blood·Thomas RansonJames P Di Santo
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas RansonJames P Di Santo
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sirirak ChantakruSharon S Evans
Jun 5, 2004·Journal of Leukocyte Biology·Mikael ErikssonCharles L Sentman
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles L SentmanMikael Eriksson
Dec 21, 2004·Molecular Immunology·Judith N Bulmer, Gendie E Lash
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xia WuDa-Jin Li
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergio RutellaGiuseppe Leone
Nov 25, 2005·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelBarbara Anne Croy
Jul 11, 2006·Seminars in Fetal & Neonatal Medicine·A M BorzychowskiC W G Redman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Derin B KeskinJack L Strominger
Apr 7, 2007·BMJ : British Medical Journal·Roy Taylor, John M Davison
Aug 4, 2007·Circulation Research·Ravi M RaoFrancis W Luscinskas
Oct 10, 2007·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelDavid A Clark
Dec 14, 2007·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelDavid A Clark
Jul 17, 2008·Journal of Leukocyte Biology·Crystal G PeraltaMarianne J van den Heuvel
Jan 24, 2009·Biology of Reproduction·Shawn P MurphyB Anne Croy
Apr 10, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Paula J WilliamsStephen C Robson
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asa AnderssonSherven Sharma
Apr 14, 2010·Journal of Immunotherapy·Annie MichaudMichel Duval
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marina CellaMarco Colonna
Jun 26, 2010·Nature Reviews. Immunology·Agnès LehuenAnne Cooke
Aug 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria MaleAshley Moffett
Apr 5, 2011·Allergy, Asthma & Immunology Research·Keisuke ObokiHirohisa Saito
Jun 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Asa AnderssonSherven Sharma

❮ Previous
Next ❯

Citations

Jun 14, 2016·Journal of Immunology Research·Cristiane de Castro Pernet HaraIracema de Mattos Paranhos Calderon
Nov 30, 2018·Frontiers in Immunology·A Inkeri LokkiHannele Laivuori
Mar 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana MichelJacques Zimmer
Oct 12, 2018·PloS One·Anna K KnightAlicia K Smith
Sep 21, 2019·IET Systems Biology·Lopamudra Dey, Anirban Mukhopadhyay
Nov 3, 2020·Frontiers in Immunology·Bahaa Abu-RayaPascal M Lavoie

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
Assay
biopsies

Software Mentioned

GraphPad
Prism
FlowJo

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.