Homo- and heteroleptic trimethoxy terpyridine-Cu(ii) complexes: synthesis, characterization, DNA/BSA binding, DNA cleavage and cytotoxicity studies

Dalton Transactions : an International Journal of Inorganic Chemistry
Surbhi JainAnuj K Sharma

Abstract

In the current study, four novel mononuclear Cu(ii) complexes with terpyridine (L) and different co-ligands (phen, bipy, and imd) were synthesized and characterized in detail, where L is 4'-(3,4,5-trimethoxyphenyl)-2,2':6',2''-terpyridine. The identity and purity of all complexes were determined by elemental analysis, spectroscopic techniques (UV-vis, FTIR, ESI-MS, and EPR) and CV, including single crystal X-ray determination of three complexes ([Cu(L)(phen)](ClO4)2 (C-I), [Cu(L)2](ClO4)2 (C-II) and [Cu(L)(imd)(ClO4)](ClO4) (C-IV). DNA binding studies were performed using fluorescence assay and the binding constants were calculated using the Stern-Volmer equation and the modified Stern-Volmer equation. The magnitude of Kapp of all complexes was 105 M-1, indicating moderate intercalative binding between CT-DNA and the complexes. Agarose gel electrophoresis clearly reflected their ability to cleave a double stranded pET-28b plasmid in the presence of an external reducing agent (3-mercapto propionic acid). Steady-state fluorescence quenching was performed to understand their interactions with BSA. The studies suggested a mixed quenching mechanism with an initial static process. Furthermore, the antiproliferative activity of the co...Continue Reading

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Methods Mentioned

BETA
ESR
electrophoresis
XRD
fluorescence displacement assay

Software Mentioned

SHELXT
GraphPad prism
SHELXL
OLEX2
PLATON

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