HOMO energy gap dependence of hole-transfer kinetics in DNA

Journal of the American Chemical Society
Kiyohiko KawaiTetsuro Majima

Abstract

DNA consists of two type of base-pairs, G-C and A-T, in which the highest occupied molecular orbital (HOMO) localizes on the purine bases G and A. While the hole transfer through consecutive Gs or As occurs faster than 10(9) s(-1), a significant drop in the hole transfer rate was observed for G-C and A-T mixed random sequences. In this study, by using various natural and artificial nucleobases having different HOMO levels, the effect of the HOMO-energy gap between bases (Δ(HOMO)) on the hole-transfer kinetics in DNA was investigated. The results demonstrated that the hole transfer rate can be increased by decreasing the Δ(HOMO) and can be finely tuned over 3 orders of magnitude by varying the Δ(HOMO).

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Citations

Apr 17, 2013·Bioorganic & Medicinal Chemistry·Ken-ichi HarunaKazuhito Tanabe
Jun 29, 2013·Accounts of Chemical Research·Kiyohiko Kawai, Tetsuro Majima
Jul 20, 2012·Journal of the American Chemical Society·Na LuChunhai Fan
Jun 9, 2012·Journal of the American Chemical Society·Raanan CarmieliMichael R Wasielewski
Aug 2, 2012·Physical Chemistry Chemical Physics : PCCP·Natalie B MurenJacqueline K Barton
Jan 12, 2016·The Journal of Physical Chemistry. a·Li-Li WangHai-Yang Liu
Oct 7, 2015·Journal of the American Chemical Society·Ajith R MalliaMahesh Hariharan
Feb 24, 2015·Chemical Communications : Chem Comm·Kiyohiko Kawai, Atsushi Maruyama
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Aug 7, 2019·Physical Chemistry Chemical Physics : PCCP·Davide AvaglianoLeticia González
Oct 11, 2019·International Journal of Molecular Sciences·Jun MaMehran Mostafavi
Feb 26, 2020·Chemistry : a European Journal·Kiyohiko Kawai, Atsushi Maruyama
Mar 19, 2015·Chemistry : a European Journal·Tadao TakadaKazushige Yamana
Mar 16, 2019·Journal of Molecular Modeling·Aleksander P WoźniakLudwik Adamowicz
Sep 11, 2012·Journal of the American Chemical Society·Arun K ThazhathveetilFrederick D Lewis

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