Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Samanta Oliveira LoureiroRegina Pessoa-Pureur

Abstract

Homocysteine is considered to be neurotoxic and a risk factor for neurodegenerative diseases. Despite the increasing evidences of excitotoxic mechanisms of homocysteine (Hcy), little is known about the action of Hcy on the cytoskeleton. In this context, the aim of the present work was to investigate the signaling pathways involved in the mechanism of action of Hcy on cytoskeletal phosphorylation in cerebral cortex and hippocampus of rats during development. Results showed that 100 microM Hcy increased the intermediate filament (IF) phosphorylation only in 17-day-old rat hippocampal slices without affecting the cerebral cortex from 9- to 29-day-old animals. Stimulation of (45)Ca(2+) uptake supported the involvement of NMDA receptors and voltage-dependent channels in extracellular Ca(2+) flux, as well as Ca(2+) release from intracellular stores through inositol-3-phosphate and ryanodine receptors. Moreover, the mechanisms underlying the Hcy effect on hippocampus cytoskeleton involved the participation of phospholipase C, protein kinase C, mitogen-activated protein kinase, phosphoinositol-3 kinase and calcium/calmodulin-dependent protein kinase II. The Hcy-induced IF hyperphosphorylation was also related to G(i) protein and inhibi...Continue Reading

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Citations

Feb 22, 2012·Biochemistry. Biokhimii︠a︡·A A BoldyrevE A Vladychenskaya
Jul 23, 2014·Oxidative Medicine and Cellular Longevity·Regina Pessoa-PureurJoão B Rocha
Nov 26, 2009·Cellular and Molecular Neurobiology·Samanta Oliveira LoureiroRegina Pessoa-Pureur
Oct 18, 2011·Neuroscience Research·Yoshika FujikiHiroaki Kanouchi
Mar 23, 2011·Neurochemistry International·Ying JinLorraine Brennan
Sep 15, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Samanta Oliveira LoureiroRegina Pessoa-Pureur
Nov 1, 2015·Journal of Alzheimer's Disease : JAD·Sungeun KimAndrew J Saykin
Oct 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Samanta Oliveira LoureiroRegina Pessoa-Pureur
Sep 1, 2015·Biochimica Et Biophysica Acta·Gurumayum Suraj SharmaLaishram Rajendrakumar Singh
Mar 22, 2014·Journal of Receptor and Signal Transduction Research·Ebru Onalan EtemGıyasettin Baydas
Jul 9, 2016·Canadian Journal of Physiology and Pharmacology·Dragan HrncicOlivera Stanojlovic
Apr 5, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Venera KhuzakhmetovaGuzel Sitdikova

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