PMID: 11914295Mar 27, 2002Paper

Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies

International Journal of Epidemiology
Earl S FordStephen B Thacker

Abstract

Elevated concentrations of homocyst(e)ine are thought to increase the risk of vascular diseases including coronary heart disease and cerebrovascular disease. We searched MEDLINE (1966-1999), EMBASE (1974-1999), SciSearch (1974- 1999), and Dissertation Abstracts (1999) for articles and theses about homocyst(e)ine concentration and coronary heart disease and cerebrovascular disease. We included 57 publications (3 cohort studies, 12 nested case-control studies, 42 case-control studies) that reported results on 5518 people with coronary heart disease (11,068 control subjects) and 1817 people with cerebrovascular disease (4787 control subjects) in our analysis. For coronary heart disease, the summary odds ratios (OR) for a 5-micromol/l increase in homocyst(e)ine concentration were 1.06 (95% CI : 0.99-1.13) for 2 publications of cohort studies, 1.23 (95% CI : 1.07-1.41) for 10 publications of nested case-control studies, and 1.70 (95% CI : 1.50-1.93) for 26 publications of case-control studies. For cerebrovascular disease, the summary OR for a 5-micromol/l increase in homocyst(e)ine concentration were 1.10 (95% CI : 0.94-1.28) for 2 publications of cohort studies, 1.58 (95% CI : 1.35-1.85) for 5 publications of nested case-control st...Continue Reading

References

Apr 1, 1976·The Journal of Clinical Investigation·D E Wilcken, B Wilcken
Mar 1, 1992·European Journal of Clinical Investigation·L BrattströmA Hamfelt
Jun 1, 1992·American Journal of Epidemiology·S Greenland, M P Longnecker
Jan 1, 1991·Journal of Clinical Epidemiology·A D Oxman, G H Guyatt
Sep 11, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J J GenestM R Malinow
Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
Jun 1, 1988·Atherosclerosis·B IsraelssonB L Hultberg
May 1, 1986·The Journal of Clinical Investigation·S S KangJ V Messer
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 1, 1987·Annals of Internal Medicine·C D Mulrow
Oct 1, 1985·Journal of the American College of Cardiology·D R Murphy-ChutorianA C Fox
Sep 19, 1985·The New England Journal of Medicine·G H BoersP W Kloppenborg
Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·L E BrattstromB L Hultberg
Apr 1, 1983·Metabolism: Clinical and Experimental·D E WilckenV J Gupta
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·P N HopkinsR R Williams
Apr 1, 1995·Journal of Internal Medicine·F LandgrenL Brattström
May 1, 1995·Stroke; a Journal of Cerebral Circulation·A LindgrenB B Johansson
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Aug 1, 1994·American Journal of Epidemiology·S Greenland
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·P VerhoefM J Stampfer
Mar 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A von EckardsteinG Assmann
Apr 1, 1994·The American Journal of Clinical Nutrition·N PancharunitiA L Cousins
Aug 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·B IsraelssonH Refsum
Sep 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·N P DudmanP Lundberg
Jan 1, 1993·The Medical Clinics of North America·B M Coull, W M Clark
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug
Oct 1, 1995·Nutrition Reviews·P Verhoef, M J Stampfer
Apr 1, 1996·Journal of the American College of Nutrition·L Chasan-TaberM J Stampfer

❮ Previous
Next ❯

Citations

Jun 30, 2010·European Journal of Nutrition·Snorri B RafnssonChittaranjan S Yajnik
Nov 1, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S Sacco, A Carolei
Jun 15, 2005·Cancer Causes & Control : CCC·Dora Il'yasovaCharles Poole
Nov 19, 2003·Metabolism: Clinical and Experimental·Mor Oron-HermanBen-Ami Sela
Dec 3, 2003·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L PisciottaS Bertolini
Jul 12, 2003·Molecular Genetics and Metabolism·Bohumila JanosíkováViktor Kozich
Dec 4, 2009·The Proceedings of the Nutrition Society·C P WilsonM Ward
Jul 15, 2009·Genetic Testing and Molecular Biomarkers·Arman HaghighatgooDaniel Darvish
Mar 29, 2008·Metabolic Syndrome and Related Disorders·J-M GarcinB Bauduceau
Feb 20, 2009·European Heart Journal·Marco RanucciRajendra H Mehta
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Dec 1, 2010·BMJ : British Medical Journal·Pilar GalanUNKNOWN SU.FOL.OM3 Collaborative Group
Dec 21, 2005·Heart·UNKNOWN British Cardiac SocietyUNKNOWN Stroke Association
Jun 15, 2007·Journal of Epidemiology and Community Health·Simon GilbodyTrevor Sheldon
May 24, 2013·Lipids in Health and Disease·Elisabet SöderströmJohan Hultdin
Dec 22, 2006·PloS One·Domenico GirelliRoberto Corrocher
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo Clerico
May 10, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Anna L BergMargret Arnadottir
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Simona Vittorini, Aldo Clerico
Mar 10, 2004·Expert Opinion on Drug Safety·Jutta DierkesClaus Luley
Nov 22, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M G H van OijenF W A Verheugt
Jul 30, 2005·European Journal of Nutrition·M MandersW H L Hoefnagels
Mar 12, 2004·American Journal of Ophthalmology·Gloria WangRobert N Weinreb
Dec 7, 2005·Spinal Cord·M Y LeeB J Kiratli
Mar 10, 2004·Journal of Women's Health·Shari S BassukJoann E Manson
May 3, 2012·Journal of Mental Health·Mahmoud A AwaraManal O Elnenaei
Jul 22, 2006·Climacteric : the Journal of the International Menopause Society·H Hachul de CamposE C Baracat
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Lei FengMichael W L Chee
Mar 3, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Arijit BiswasRenu Saxena
Jul 15, 2004·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·L HooperUNKNOWN UK Heart Health and Thoracic Dietitians Specialist Group of the British Dietetic Association
Sep 15, 2004·The Journal of Clinical Hypertension·Rajani Dinavahi, Bonita Falkner

❮ Previous
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