Homocysteine and folate concentrations in blood from patients treated with hemodialysis.

Journal of the American Society of Nephrology : JASN
T TamuraS M Bergman

Abstract

Plasma homocysteine and plasma and erythrocyte folate concentrations before and after hemodialysis were measured in 31 patients with ESRD. Homocysteine and folate were measured by HPLC-fluorometric and microbiological methods, respectively. The mean plasma homocysteine level declined from 36.8 to 24.2 mumol/L during hemodialysis, indicating that homocysteine can be partly removed by hemodialysis (P < 0.0001). Mean plasma folate concentration before hemodialysis was 46.4 nmol/L and decreased to 25.9 nmol/L after hemodialysis (P < 0.0001), whereas mean erythrocyte folate concentration did not change (1295 and 1385 nmol/L before and after hemodialysis, respectively). Plasma folate concentrations showed a significant negative correlation with homocysteine concentrations before and after hemodialysis (r = -0.53, P < 0.003, and r = -0.59, P < 0.001, respectively). Furthermore, there were significant negative correlations between plasma homocysteine and erythrocyte folate concentrations both before (r = -0.60, P < 0.0005) and after hemodialysis (r = -0.49, P < 0.005). All patients had homocysteine concentrations over 12.0 mumol/L before hemodialysis, and only three had homocysteine concentrations lower than 12.0 mumol/L after hemodial...Continue Reading

Citations

Mar 5, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yun LiTongying Zhu
Apr 1, 2000·The Journal of Nutritional Biochemistry·K H HongT Tamura
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·Hideki KimuraRyoichi Miyazaki
Apr 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·K PagánT Tamura
Jun 26, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S M SecorT Tamura
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Kayo ShinoharaYoshiki Nishizawa
Jun 3, 1999·Biochimica Et Biophysica Acta·T TamuraC L Keen
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jenq-Wen HuangBor-Shen Hsieh
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·An S De VrieseErvé Matthys
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Helmut Schiffl, Susanne M Lang
Feb 15, 2007·European Journal of Clinical Nutrition·J E Baggott, T Tamura
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Bradley L UrquhartAndrew A House
Dec 17, 2008·The British Journal of Nutrition·Young-Hee HanTaisun H Hyun
Feb 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ronald G MungerJohn C Carey

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