Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease

Cytokine
Cahide GokkusuMakbule Aydin

Abstract

Inflammation is involved in development and progression of atherosclerosis. Interleukin-2 (IL-2) and interleukin-6 (IL-6) have been correlated with various cardiovascular diseases. Hyperhomocysteinemia is an important risk factor for atherosclerosis and thrombotic disease. Recent studies have demonstrated that homocysteine (Hcy) enhances productions of several pro-inflammatory cytokines. In the light of these findings, we decided to determine if any relationship exists between IL-2 and IL-6, the pro-inflammatory cytokines, and total homocysteine (tHcy) in acute coronary syndrome (ACS). A total of 102 patients with ACS and 90 healthy subjects were included in the study. The levels of tHcy, IL-2 and IL-6 were higher and folic acid was lower in patients as compared with those of controls. Furthermore, data of the area under ROC plot for IL-2 demonstrated that IL-2 had higher sensitivity. These data suggest that enhanced inflammation may be associated with tHcy-related cardiovascular disease.

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Citations

Aug 10, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·William M L Neethling, Andrew J Hodge
Jan 25, 2011·Journal of Natural Medicines·Yazmin RaveloRosa Más
Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad A AminzadehNosratola D Vaziri
Aug 10, 2010·Neurobiology of Aging·Auriel A WilletteSterling C Johnson
Mar 7, 2020·Biomolecules·Nehal M ElsherbinyAmany Tawfik
Jul 3, 2021·International Journal of Molecular Sciences·Amany TawfikPragya Rajpurohit

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