Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium

Science
M A De GrooteF C Fang

Abstract

Nitric oxide (NO) is associated with broad-spectrum antimicrobial activity of particular importance in infections caused by intracellular pathogens. An insertion mutation in the metL gene of Salmonella typhimurium conferred specific hypersusceptibility to S-nitrosothiol NO-donor compounds and attenuated virulence of the organism in mice. The metL gene product catalyzes two proximal metabolic steps required for homocysteine biosynthesis. S-Nitrosothiol resistance was restored by exogenous homocysteine or introduction of the metL gene on a plasmid. Measurement of expression of the homocysteine-sensitive metH gene indicated that S-nitrosothiols may directly deplete intracellular homocysteine. Homocysteine may act as an endogenous NO antagonist in diverse processes including infection, atherosclerosis, and neurologic disease.

References

Sep 1, 1991·Infection and Immunity·K A RockettI A Clark
Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
Dec 1, 1989·Molecular Microbiology·B B Finlay, S Falkow
Sep 19, 1985·The New England Journal of Medicine·G H BoersP W Kloppenborg
May 1, 1984·Journal of Bacteriology·B A CastilhoM J Casadaban
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M KatinkaM Yaniv
Sep 22, 1995·Cell·C Nathan
Jun 1, 1995·Microbiological Reviews·K E SandersonK E Rudd
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A De GrooteF C Fang
Feb 2, 1995·The New England Journal of Medicine·M J Stampfer, M R Malinow
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C TsaiM E Lee
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B GastonD J Singel
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A De Groote, F C Fang

❮ Previous
Next ❯

Citations

Jun 5, 2004·Comparative Immunology, Microbiology and Infectious Diseases·Angela Berndt, Ulrich Methner
Oct 15, 1998·International Journal for Parasitology·M E SelkirkK Gounaris
Jan 1, 1997·Life Sciences·S R Lentz
Mar 10, 2000·Biochimica Et Biophysica Acta·Y MiyamotoH Maeda
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Aug 6, 2000·Free Radical Biology & Medicine·N Hogg
Feb 19, 2000·Current Opinion in Immunology·C BogdanA Diefenbach
Feb 13, 2001·Trends in Microbiology·A Vazquez-Torres, F C Fang
Sep 19, 1997·Trends in Microbiology·E A Groisman, H Ochman
Aug 8, 2001·Microbes and Infection·B J Cherayil, D Antos
Jun 6, 2003·Microbes and Infection·Dipshikha Chakravortty, Michael Hensel
Sep 21, 2004·Nature Reviews. Microbiology·Ferric C Fang
Oct 6, 2000·Journal of Applied Microbiology·A C RodriguesL Q Vieira
Feb 13, 2001·Molecular Microbiology·D Tezcan-MerdolM Rhen
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei KongRoy Curtiss
Sep 1, 2005·The Journal of Experimental Medicine·Bruce D McCollisterAndrés Vázquez-Torres
Jul 10, 2012·Antioxidants & Redox Signaling·Jay R LaverRobert K Poole
Oct 9, 2007·Applied and Environmental Microbiology·Yanyan HuangCraig Altier
Jan 5, 2000·Clinical and Diagnostic Laboratory Immunology·B StoiserH Burgmann
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·J F HuntB Gaston
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Ashley H SnyderBenjamin Gaston
Oct 6, 1997·The Journal of Clinical Investigation·C ZaragozaC J Lowenstein
Sep 19, 2001·American Journal of Veterinary Research·D McFarlaneS A Gibbs
Jun 10, 2006·International Journal of Biological Sciences·Laura GodoyRicard Albalat
May 26, 2001·Biochemical and Biophysical Research Communications·K ZamanL A Palmer
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Nathan, M U Shiloh
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Florent SebbaneB Joseph Hinnebusch
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·M A De GrooteF C Fang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.